Sustainable delivery system based on biocellulose/metallic complexes containing bioactive ligands

• Grant number: 15/09833-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2015
• End date: September 30, 2017
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Wilton Rogério Lustri
• Grantee: Wilton Rogério Lustri
• Host Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil
• Associated researchers: André Capaldo Amaral ; Antonio Carlos Massabni ; Flávia Aparecida Resende Nogueira ; Hernane da Silva Barud ; Pedro Paulo Corbi

Abstract

Bioactive metal complexes with ligands have been used for some time to treat illnesses such as infections by different types of microorganisms, arthritis and cancer, which makes it interesting to conduct studies aiming at the synthesis of new complex and the testing in vitro and in vivo, for the determination and understanding of their pharmacological and molecular mechanisms of action. It has been as an example of such complexes, silver sulfadiazine used in the treatment of infections in burn injury, cisplatin, in the treatment of cancer and auranofin in the treatment of arthritis. Currently, the use of biopolymers as support and drug delivery is gaining importance in medicine. Among these polymers, bacterial cellulose holds great promise for biomedical applications due to its combination of biocompatibility and versatility. CB in different shapes, has already been applied in the treatment of various types of lesions. CB membranes were initially used as barriers and supports the regeneration of periodontal tissues, temporary artificial skin for burns and ulcers and artificial blood vessels for microsurgery. Thus, this research project aims to the synthesis, characterization and pharmacological application of new copper (II) complexes, silver (I), palladium (II), platinum (II) and gold (I) with ligands , furosemide, indapamide, chlorthalidone, hydrochlorothiazide and zileutona in the treatment of bacterial infections, as well as achieving inhibition of cell growth in vitro and the biosynthesis and modification of bacterial cellulose membranes for use as a controlled release carrier such metal complexes. (AU)

Scientific publications

(21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIORI, ANA THEREZA M.; NAKAHATA, DOUGLAS H.; CUIN, ALEXANDRE; LUSTRI, WILTON R.; CORBI, PEDRO P.. Synthesis, crystallographic studies, high resolution mass spectrometric analyses and antibacterial assays of silver(I) complexes with sulfisoxazole and sulfadimethoxine. Polyhedron, v. 121, p. 172-179, JAN 10 2017. (15/09833-0, 15/25114-4, 15/20882-3)

NAKAHATA, DOUGLAS H.; LUSTRI, WILTON R.; CUIN, ALEXANDRE; CORBI, PEDRO P.. Crystal structure, spectroscopic characterization and antibacterial activities of a silver complex with sulfameter. Journal of Molecular Structure, v. 1125, p. 609-615, DEC 5 2016. (15/09833-0, 15/25114-4, 15/20882-3)

LAZARINI, S. C.; YAMADA, C.; BARUD, H. S.; TROVATTI, E.; CORBI, P. P.; LUSTRI, W. R.. Influence of chemical and physical conditions in selection of Gluconacetobacter hansenii ATCC 23769 strains with high capacity to produce bacterial cellulose for application as sustained antimicrobial drug-release supports. Journal of Applied Microbiology, v. 125, n. 3, p. 777-791, SEP 2018. (15/09833-0, 15/25114-4, 16/17278-0)

SIMEI AQUARONI, NAYARA AP.; NAKAHATA, DOUGLAS H.; LAZARINI, SILMARA C.; RESENDE, FLAVIA A.; CANDIDO, AMANDA L. P.; BARUD, HERNANE DA SILVA; CLARO, AMANDA MARIA; DE CARVALHO, JOAO ERNESTO; RIBEIRO, CAMILA M.; PAVAN, FERNANDO R.; et al. Antibacterial activities and antiproliferative assays over a tumor cells panel of a silver complex with 4-aminobenzoic acid: Studies in vitro of sustained release using bacterial cellulose membranes as support. Journal of Inorganic Biochemistry, v. 212, NOV 2020. (17/19243-1, 15/09833-0, 17/16278-9, 18/12062-4, 16/07729-4, 13/07276-1, 18/12590-0, 18/25512-8, 14/06779-2, 19/03049-7, 18/02344-2, 18/00163-0, 15/20882-3)

NAKAHATA, DOUGLAS H.; DE PAIVA, RAPHAEL E. F.; LUSTRI, WILTON R.; RIBEIRO, CAMILA M.; PAVAN, FERNANDO R.; DA SILVA, GISELE G.; RUIZ, ANA L. T. G.; DE CARVALHO, JOAO E.; CORBI, PEDRO P.. Sulfonamide-containing copper(II) metallonucleases: Correlations with in vitro antimycobacterial and antiproliferative activities. Journal of Inorganic Biochemistry, v. 187, p. 85-96, OCT 2018. (15/09833-0, 15/25114-4, 15/20882-3)

GOMES, S. Q.; VITORIANO, L.; DE ARRUDA, E. G. R.; RUIZ, A. L. T. G.; CANDIDO, T.; DE CARVALHO, J. E.; LUSTRI, W. R.; ABBEHAUSEN, C.. Linear gold(I) complex with tris-(2-carboxyethyl)phosphine (TCEP): Selective antitumor activity and inertness toward sulfur proteins. Journal of Inorganic Biochemistry, v. 186, p. 104-115, SEP 2018. (15/09833-0, 17/12719-0)

CANDIDO, TUANY ZAMBROTI; FERRAZ DE PAIVA, RAPHAEL ENOQUE; FIGUEIREDO, MARIANA CECCHETTO; COSER, LILIAN DE OLIVEIRA; LAZARINI FRAJACOMO, SILMARA CRISTINA; ABBEHAUSEN, CAMILLA; CARDINALLI, IZILDA APARECIDA; LUSTRI, WILTON ROGERIO; CARVALHO, JOAO ERNESTO; TASCA GOIS RUIZ, ANA LUCIA; et al. Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma. PHARMACEUTICS, v. 14, n. 2, p. 18-pg., 2022-02-01. (16/07729-4, 18/12062-4, 15/09833-0, 17/12719-0, 18/12590-0)

NAKAHATA, DOUGLAS H.; DE PAIVA, RAPHAEL E. F.; LUSTRI, WILTON R.; CORBI, PEDRO P.. Sulfonamide-containing copper(ii) complexes: new insights on biophysical interactions and antibacterial activities. NEW JOURNAL OF CHEMISTRY, v. 44, n. 40, p. 9-pg., 2020-10-28. (15/09833-0, 15/20882-3, 18/12062-4, 18/21537-6, 18/12590-0, 15/25114-4)

MANZANO, CARLOS M.; BERGAMINI, FERNANDO R. G.; FORMIGA, ANDRE L. B.; CORBI, PEDRO P.; RUIZ, ANA LUCIA T. G.; DE OLIVEIRA, ELLEN C. S.; LUSTRI, WILTON R.; RIBEIRO, MARCOS A.. Pt(II) and Pd(II) complexes with ibuprofen hydrazide: Characterization, theoretical calculations, antibacterial and antitumor assays and studies of interaction with CT-DNA (vol 1154, pg 469, 2018). Journal of Molecular Structure, v. 1208, p. 1-pg., 2020-05-15. (15/09833-0)

SIMEI AQUARONI, NAYARA APARECIDA; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO; LUSTRI, WILTON ROGERIO. Antibacterial activities of a Ag(I) complex with 4-aminobenzoic acid. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., 2017-07-01. (15/20882-3, 15/25114-4, 15/09833-0)

LUSTRI, WILTON ROGERIO; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO; LAZARINI, SILMARA CRISTINA; TROVATTI, ELIANE. 1-Hydroxibenzotriazole-silver complex: synthesis and biological activities. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., 2017-07-01. (15/25114-4, 15/09833-0)

LUSTRI, WILTON R.; LAZARINI, SILMARA C.; LUSTRI, BRUNA CARDINALI; CORBI, PEDRO P.; SILVA, MARIA ALINE C.; RESENDE NOGUEIRA, FLAVIA APARECIDA; AQUINO, RENATA; AMARAL, ANDRE C.; TREU FILHO, OSWALDO; MASSABNI, ANTONIO CARLOS; et al. Spectroscopic characterization and biological studies in vitro of a new silver complex with furosemide: Prospective of application as an antimicrobial agent. Journal of Molecular Structure, v. 1134, p. 386-394, APR 15 2017. (15/09833-0, 15/25114-4, 12/08230-2)

NUNES, JULIA H. B.; NAKAHATA, DOUGLAS H.; LUSTRI, WILTON R.; CORBI, PEDRO P.; DE PAIVA, RAPHAEL E. F.. The nitro-reduced metabolite of nimesulide: Crystal structure, spectroscopic characterization, ESI-QTOF mass spectrometric analysis and antibacterial evaluation. Journal of Molecular Structure, v. 1157, p. 469-475, APR 5 2018. (15/09833-0, 12/21955-6, 15/20882-3)

FIORI-DUARTE, ANA THEREZA; BERGAMINI, FERNANDO R. G.; DE PAIVA, RAPHAEL ENOQUE E.; MANZANO, CARLOS M.; LUSTRI, WILTON R.; CORBI, PEDRO P.. A new palladium(II) complex with ibuprofen: Spectroscopic characterization, DFT studies, antibacterial activities and interaction with biomolecules. Journal of Molecular Structure, v. 1186, p. 144-154, JUN 15 2019. (18/12062-4, 15/25114-4, 10/00667-7, 17/25995-6, 15/09833-0)

FIORI-DUARTE, ANA THEREZA; DE PAIVA, RAPHAEL ENOQUE F.; MANZANO, CARLOS M.; LUSTRI, WILTON R.; CORBI, PEDRO P.. Silver(I) and gold(I) complexes with sulfasalazine: Spectroscopic characterization, theoretical studies and antiproliferative activities over Gram-positive and Gram-negative bacterial strains. Journal of Molecular Structure, v. 1214, AUG 15 2020. (18/12062-4, 18/12590-0, 17/25995-6, 15/09833-0)

CIOL, MARIANA ROSOLEN; MANZANO, CARLOS MARROTE; CUIN, ALEXANDRE; PAVAN, FERNANDO ROGERIO; RIBEIRO, CAMILA MARINGOLO; TASCA GOIS RUIZ, ANA LUCIA; DE OLIVEIRA, ELLEN CRISTINA S.; LUSTRI, WILTON ROGERIO; FREGONEZI, NATHALIA FERREIRA; RESENDE NOGUEIRA, FLAVIA APARECIDA; et al. A Silver Complex with Cycloserine: Synthesis, Spectroscopic Characterization, Crystal Structure and In Vitro Biological Studies. CHEMISTRYSELECT, v. 3, n. 6, p. 1719-1726, FEB 14 2018. (15/09833-0, 15/25114-4)

YAMAMOTO, LAIS MEGUMI; BORMIO NUNES, JULIA HELENA; RIBEIRO, MARCOS ANTONIO; DA COSTA FERREIRA, ANA MARIA; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. Copper(II) and silver(I) complexes with sulfamethizole: synthesis, spectroscopic characterization, ESI-QTOF mass spectrometric analysis, crystal structure and antibacterial activities. Polyhedron, v. 138, p. 168-176, DEC 14 2017. (15/09833-0, 16/01579-0, 15/25114-4)

QUINTANILHA, MARIANA MAZZO; SCHIMITD, BIANCA ALVES; COSTA, ADAO MARCOS FERREIRA; NAKAHATA, DOUGLAS HIDEKI; SIMONI, DEBORAH DE ALENCAR; CLAVIJO, JUAN CARLOS TENORIO; PEREIRA, DOUGLAS HENRIQUE; MASSABNI, ANTONIO CARLOS; LUSTRI, WILTON ROGERIO; CORBI, PEDRO PAULO. A novel water-soluble platinum(II) complex with the amino acid deoxyalliin: synthesis, crystal structure, theoretical studies and investigations about its antibacterial activity. Journal of Molecular Structure, v. 1236, JUL 15 2021. (13/08293-7, 15/20882-3, 18/09860-6, 18/09856-9, 18/12590-0, 15/09833-0, 18/12062-4, 17/11485-6)

LUSTRI, WILTON R.; LAZARINI, SILMARA C.; AQUARONI, NAYARA AP SIMEI; RESENDE, FLAVIA A.; ALEIXO, NADIA A.; PEREIRA, DOUGLAS H.; LUSTRI, BRUNA CARDINALI; MOREIRA, CRISTIANO GALLINA; RIBEIRO, CAMILA M.; PAVAN, FERNANDO R.; et al. A new complex of silver(I) with probenecid: Synthesis, characterization, and studies of antibacterial and extended spectrum beta-lactamases (ESBL) inhibition activities. Journal of Inorganic Biochemistry, v. 243, p. 12-pg., 2023-03-30. (18/00163-0, 19/03049-7, 15/09833-0, 15/20882-3, 18/12062-4, 17/16278-9, 21/07458-9, 17/19243-1, 20/13497-4, 18/12590-0, 19/26696-8, 18/00187-7, 21/08717-8, 18/02344-2)

NAKAHATA, DOUGLAS HIDEKI; FERRAZ DE PAIVA, RAPHAEL ENOQUE; LUSTRI, WILTON ROGERIO; RIBEIRO, CAMILA MARINGOLO; PAVAN, FERNANDO ROGERIO; CORBI, PEDRO PAULO. Copper(II) complexes with sulfonamides: crystal structures, biophysical assays and antimycobacterial activity. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., 2017-07-01. (15/20882-3, 15/25114-4, 15/09833-0)

LAZARINI, SILMARA CRISTINA; CORBI, PEDRO PAULO; LUSTRI, WILTON ROGERIO. Release capacity in bacterial cellulose membranes of antibacterial Ag(I) metal complex with furosemide. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 22, p. 1-pg., 2017-07-01. (15/25114-4, 15/09833-0)

Filed patent(s) as a result of this research project