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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Milestones in Friedreich ataxia: more than a century and still learning

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Autor(es):
Abrahao, Agessandro [1, 2, 3] ; Pedroso, Jose Luiz [1, 2, 3] ; Braga-Neto, Pedro [4] ; Bor-Seng-Shu, Edson [5] ; Aguiar, Patricia de Carvalho [1, 6] ; Povoas Barsottini, Orlando Graziani [1, 2, 3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Gen Neurol, BR-04039002 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Ataxia Unit, BR-04039002 Sao Paulo, SP - Brazil
[4] Univ Estadual Ceara, Ctr Hlth Sci, Fortaleza, Ceara - Brazil
[5] Univ Sao Paulo, Sch Med, Div Neurol Surg, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, UNIFESP, Div Movement Disorders, BR-04039002 Sao Paulo, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: NEUROGENETICS; v. 16, n. 3, p. 151-160, JUL 2015.
Citações Web of Science: 19
Resumo

Friedreich ataxia (FRDA) is the most common autosomal recessive ataxia worldwide. This review highlights the main clinical features, pathophysiological mechanisms, and therapeutic approaches for FRDA patients. The disease is characterized by a combination of neurological involvement (ataxia and neuropathy), cardiomyopathy, skeletal abnormalities, and glucose metabolism disturbances. FRDA is caused by expanded guanine-adenine-adenine (GAA) triplet repeats in the first intron of the frataxin gene (FXN), resulting in reduction of messenger RNA and protein levels of frataxin in different tissues. The molecular and metabolic disturbances, including iron accumulation, lead to pathological changes characterized by spinal cord and dorsal root ganglia atrophy, dentate nucleus atrophy without global cerebellar volume reduction, and hypertrophic cardiomyopathy. DNA analysis is the hallmark for the diagnosis of FRDA. There is no specific treatment to stop the disease progression in FRDA patients. However, a number of drugs are under investigation. Therapeutic approaches intend to improve mitochondrial functioning and to increase FXN expression. (AU)

Processo FAPESP: 12/17494-3 - Estudo da expressão gênica nas células do sangue periférico de pacientes com ataxia de Friedreich
Beneficiário:Orlando Graziani Povoas Barsottini
Modalidade de apoio: Auxílio à Pesquisa - Regular