Ancient DNA sequence revealed by error-correcting codes

Autor(es)

Brandao, Marcelo M. ^{[1, 2]} ; Spoladore, Larissa ^[2] ; Faria, Luzinete C. B. ^[3] ; Rocha, Andrea S. L. ^[3] ; Silva-Filho, Marcio C. ^[2] ; Palazzo, Jr., Reginaldo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Ctr Biol Mol & Engn Genet, Campinas, SP - Brazil

^[2] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Genet, BR-13400918 Piracicaba, SP - Brazil

^[3] Univ Estadual Campinas, Fac Engn Eletr & Computacao, Dept Telemat, BR-13081970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 5, JUL 10 2015.
• Citações Web of Science: 2

Resumo

A previously described DNA sequence generator algorithm (DNA-SGA) using error-correcting codes has been employed as a computational tool to address the evolutionary pathway of the genetic code. The code-generated sequence alignment demonstrated that a residue mutation revealed by the code can be found in the same position in sequences of distantly related taxa. Furthermore, the code-generated sequences do not promote amino acid changes in the deviant genomes through codon reassignment. A Bayesian evolutionary analysis of both code-generated and homologous sequences of the Arabidopsis thaliana malate dehydrogenase gene indicates an approximately 1 MYA divergence time from the MDH code-generated sequence node to its paralogous sequences. The DNA-SGA helps to determine the plesiomorphic state of DNA sequences because a single nucleotide alteration often occurs in distantly related taxa and can be found in the alternative codon patterns of noncanonical genetic codes. As a consequence, the algorithm may reveal an earlier stage of the evolution of the standard code. (AU)

• Processo FAPESP: 11/00417-3 - Biologia de sistemas aplicada a agricultura: análise de transcriptomas e interactomas
• Beneficiário: Marcelo Mendes Brandao
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/04992-0 - Código matemático de geração e decodificação de sequências de DNA e proteínas: utilização na identificação de ligantes e receptores
• Beneficiário: Márcio de Castro Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Programa de Apoio à Propriedade Intelectual (PAPI/Nuplitec)
• Processo FAPESP: 08/52067-3 - Herbivoria e o transporte intracelular de proteínas
• Beneficiário: Márcio de Castro Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Temático