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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ancient DNA sequence revealed by error-correcting codes

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Author(s):
Brandao, Marcelo M. [1, 2] ; Spoladore, Larissa [2] ; Faria, Luzinete C. B. [3] ; Rocha, Andrea S. L. [3] ; Silva-Filho, Marcio C. [2] ; Palazzo, Jr., Reginaldo [3]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Ctr Biol Mol & Engn Genet, Campinas, SP - Brazil
[2] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Genet, BR-13400918 Piracicaba, SP - Brazil
[3] Univ Estadual Campinas, Fac Engn Eletr & Computacao, Dept Telemat, BR-13081970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 5, JUL 10 2015.
Web of Science Citations: 2
Abstract

A previously described DNA sequence generator algorithm (DNA-SGA) using error-correcting codes has been employed as a computational tool to address the evolutionary pathway of the genetic code. The code-generated sequence alignment demonstrated that a residue mutation revealed by the code can be found in the same position in sequences of distantly related taxa. Furthermore, the code-generated sequences do not promote amino acid changes in the deviant genomes through codon reassignment. A Bayesian evolutionary analysis of both code-generated and homologous sequences of the Arabidopsis thaliana malate dehydrogenase gene indicates an approximately 1 MYA divergence time from the MDH code-generated sequence node to its paralogous sequences. The DNA-SGA helps to determine the plesiomorphic state of DNA sequences because a single nucleotide alteration often occurs in distantly related taxa and can be found in the alternative codon patterns of noncanonical genetic codes. As a consequence, the algorithm may reveal an earlier stage of the evolution of the standard code. (AU)

FAPESP's process: 11/00417-3 - System biology techniques applied to the agriculture: transcriptomes and interactomes analyses
Grantee:Marcelo Mendes Brandao
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 08/52067-3 - Herbivory and intracellular transport of proteins
Grantee:Márcio de Castro Silva Filho
Support Opportunities: Program for Research on Bioenergy (BIOEN) - Thematic Grants