The assembly of dialkyldimethylammonium bromide cationic lipids as vesicles or monolayers in presence of poly(ethylene glycol)

Autor(es)

Adati, Renata D. ^[1] ; Feitosa, Eloi ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Thermochimica Acta; v. 613, p. 71-76, AUG 10 2015.
• Citações Web of Science: 1

Resumo

The interaction between polymer and lipid vesicles may result in stabilization and formation of highly ordered networks, which can mimic biological membranes and be used as drug delivery system. Here we used differential scanning calorimetry (DSC) and Langmuir-Blodgett (LB) techniques to describe the effect of the nonionic water-soluble poly(ethylene glycol), PEG 35 kDa, on vesicles or monolayers from the cationic dialkyldimethylammonium bromide, D(n)DAB (n = 12-18). Based on DSC data, up to 10 Wt%, PEG plays minor role on the thermal behavior of D(n)DAB, thus preserving the bilayer structure. Above 10 wt% PEG, there is no bilayer for n = 12-16, while for n = 18 there remains bilayer structures even in presence of 30 wt% PEG. The effect of PEG on the Langmuir monolayer of D(18)DAB depends on the amount of PEG in the sub-phase. In presence of up to ca 1 wt%, PEG yields more compressible films, while at higher polymer concentration the film is more extended and the collapse pressure is lower, most probably due to lipid solubility by the polymer solution. The PEG-D,DAB complexes have potential application in controlled drug release by microgel nanoparticles. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/03566-0 - Estudos de sistemas auto-organizados de brometo de dialquildimetilamônio (DnDAB) em solução aquosa e interfaces líquidas e sólidas
• Beneficiário: Eloi da Silva Feitosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/07414-0 - Estudo da interação entre polímeros hidrossolúveis e lipídios catiônicos em solução vesicular e em filmes moleculares como modelos de sistemas biomiméticos
• Beneficiário: Renata Danielle Adati
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado