| Texto completo | |
| Autor(es): |
Vieira, Daniele Goncalves
[1, 2]
;
Costa-Carvalho, Beatriz Tavares
[1]
;
Hix, Sonia
[3]
;
da Silva, Rosangela
[4]
;
Correia, Milena S. G.
[3]
;
Saccardo Sarni, Roseli Oselka
[3, 1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Sao Paulo, SP - Brazil
[2] Midwest State Univ, Guarapuava, Parana - Brazil
[3] ABC Univ, Santo Andre, SP - Brazil
[4] Univ Fed Alfenas, Alfenas, MG - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ANNALS OF NUTRITION AND METABOLISM; v. 66, n. 4, p. 237-241, 2015. |
| Citações Web of Science: | 2 |
| Resumo | |
Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. (C) 2015 S. Karger AG, Basel (AU) | |
| Processo FAPESP: | 11/13336-1 - Avaliação do perfil lipídico e das apoliproteínas A1 e B: relação com enzimas associadas ao risco cardiovascular em pacientes com hipogamaglobulinemia |
| Beneficiário: | Roseli Oselka Saccardo Sarni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |