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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients

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Author(s):
Vieira, Daniele Goncalves [1, 2] ; Costa-Carvalho, Beatriz Tavares [1] ; Hix, Sonia [3] ; da Silva, Rosangela [4] ; Correia, Milena S. G. [3] ; Saccardo Sarni, Roseli Oselka [1, 3]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Sao Paulo, SP - Brazil
[2] Midwest State Univ, Guarapuava, Parana - Brazil
[3] ABC Univ, Santo Andre, SP - Brazil
[4] Univ Fed Alfenas, Alfenas, MG - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ANNALS OF NUTRITION AND METABOLISM; v. 66, n. 4, p. 237-241, 2015.
Web of Science Citations: 2
Abstract

Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. (C) 2015 S. Karger AG, Basel (AU)

FAPESP's process: 11/13336-1 - Evaluation of the lipid profile and apolipropotein A1 and B: relationship with enzymes associated with cardiovascular risk in patients with hypogammaglobulinemia
Grantee:Roseli Oselka Saccardo Sarni
Support type: Regular Research Grants