Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients

Author(s)

Vieira, Daniele Goncalves ^{[1, 2]} ; Costa-Carvalho, Beatriz Tavares ^[1] ; Hix, Sonia ^[3] ; da Silva, Rosangela ^[4] ; Correia, Milena S. G. ^[3] ; Saccardo Sarni, Roseli Oselka ^{[3, 1]}

Affiliation

^[1] Univ Fed Sao Paulo, Sao Paulo, SP - Brazil

^[2] Midwest State Univ, Guarapuava, Parana - Brazil

^[3] ABC Univ, Santo Andre, SP - Brazil

^[4] Univ Fed Alfenas, Alfenas, MG - Brazil

• Document type: Journal article
• Source: ANNALS OF NUTRITION AND METABOLISM; v. 66, n. 4, p. 237-241, 2015.
• Web of Science Citations: 2

Abstract

Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk. (C) 2015 S. Karger AG, Basel (AU)

• FAPESP's process: 11/13336-1 - Evaluation of the lipid profile and apolipropotein A1 and B: relationship with enzymes associated with cardiovascular risk in patients with hypogammaglobulinemia
• Grantee: Roseli Oselka Saccardo Sarni
• Support Opportunities: Regular Research Grants