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Evaluation of the lipid profile and apolipropotein A1 and B: relationship with enzymes associated with cardiovascular risk in patients with hypogammaglobulinemia

Grant number: 11/13336-1
Support type:Regular Research Grants
Duration: October 01, 2011 - September 30, 2013
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Roseli Oselka Saccardo Sarni
Grantee:Roseli Oselka Saccardo Sarni
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Beatriz Tavares Costa Carvalho ; Daniele Gonçalves Vieira ; Rosangela da Silva ; Sonia Hix


Primary immunodeficiencies (PID's) are characterized by qualitative defects and/or quantitative, genetically determined, in one or more sectors of the immune system, which is responsible for protecting the body. The estimated prevalence of IDP's is 1:10.000. The Common Variable Immunodeficiency (CVI) and X-linked agammaglobulinemia (XLA) are classified as antibody deficiencies resulting in hypogammaglobulinemia. In similarity with other chronic diseases, PIDs may occur with inflammatory disorders, endocrines and the exacerbation of oxidative stress. The aim of this study is to determine the lipid profile of patients with CVI and XLA and verify its association with nutritional status, lifestyle and food habits with enzymes and inflammatory marker related to cardiovascular risk. Will be evaluated through sectional study, prospective, controlled the 30 patients diagnosed with CVI and XLA, of both sexes, aged between 2 and 54 years old enrolled at the Department of Pediatrics, UNIFESP. Anthropometric assessment will be undertaken - such as weight, height, waist and brachial circumference and skinfold - and biochemical evaluation - by means of serum dosage of total cholesterol and fractions HDL-C (High Density Lipoprotein) and LDL-C (Low Density Lipoprotein) with analysis of APOB and APOA-1 (the main protein components of HDL-C and LDL-c) and quantification of sdLDL-C (smaller and denser fraction of LDL-C), triglycerides, C-reactive protein and the paraoxonase enzymes, myeloperoxidase, transference protein of cholesterol esters and lecithin: cholesterol acyltransferase. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, DANIELE GONCALVES; COSTA-CARVALHO, BEATRIZ TAVARES; HIX, SONIA; DA SILVA, ROSANGELA; CORREIA, MILENA S. G.; SACCARDO SARNI, ROSELI OSELKA. Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients. ANNALS OF NUTRITION AND METABOLISM, v. 66, n. 4, p. 237-241, 2015. Web of Science Citations: 2.

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