Can mouth washes containing chlorhexidine 0.12% be used as synonym of a water solution of chlorhexidine 0.12%?

Autor(es)

Suffredini, Ivana Barbosa ^[1] ; Coury Saraceni, Cintia Helena ^[2] ; Collantes Diaz, Ingrit Elida ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Ctr Res Biodivers, Extract Lab, BR-01310100 Sao Paulo, SP - Brazil

^[2] Univ Estadual Paulista, Sch Dent Grad Program Dent, BR-01310100 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 51, n. 2, p. 367-372, APR-JUN 2015.
• Citações Web of Science: 1

Resumo

<p>Chlorhexidine digluconate (CHX) is a gold standard drug in dentistry and is widely used as a reference in both <italic>in vitro</italic> and <italic>in vivo</italic>experiments. Due to ease of access, mouth washes containing CHX 0.12% are used as a substitute for aqueous CHX 0.12% solution in laboratory experiments. Additionally, it is well known that for product flavor purposes, volatile compounds are added to mouth washes formulations. Volatiles added to CHX 0.12% may improve wash's antibacterial ability. Volatiles add potency to the mouth wash formulation. Compared with an aqueous CHX 0.12% solution, it is proposed that CHX solutions and Periogard^® would have antimicrobial activity. Antimicrobial activity was assessed in the present study via disk diffusion assays against <italic>Streptococcus mutans</italic>, <italic>Streptococcus sanguinis</italic>and <italic>Escherichia coli</italic>. Periogard^® showed a significantly higher antibacterial activity in relation to CHX 0.12% (p<0.05) and a similar activity in relation to CHX 1% (p>0.05). Periogard^(r) volatiles were analyzed by gas-chromatography/mass spectrometry (GCMS) and the presence of antibacterial menthol, menthone, isomenthol, menthyl acetate, trans-anethol and eugenol was verified. Finally, the use of Periogard^® as a synonym of CHX 0.12% must be avoided, because its antibacterial activity is closely related to CHX 1%.</p> (AU)

• Processo FAPESP: 08/58706-8 - Avaliação da atividade antitumoral, antibacteriana e ação sobre o sistema nervoso central e hormônios de extratos obtidos de plantas amazônicas e da Mata Atlântica
• Beneficiário: Ivana Barbosa Suffredini
• Modalidade de apoio: Auxílio à Pesquisa - Regular