Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Can mouth washes containing chlorhexidine 0.12% be used as synonym of a water solution of chlorhexidine 0.12%?

Full text
Author(s):
Suffredini, Ivana Barbosa [1] ; Coury Saraceni, Cintia Helena [2] ; Collantes Diaz, Ingrit Elida [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Paulista, Ctr Res Biodivers, Extract Lab, BR-01310100 Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, Sch Dent Grad Program Dent, BR-01310100 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 51, n. 2, p. 367-372, APR-JUN 2015.
Web of Science Citations: 1
Abstract

<p>Chlorhexidine digluconate (CHX) is a gold standard drug in dentistry and is widely used as a reference in both <italic>in vitro</italic> and <italic>in vivo</italic>experiments. Due to ease of access, mouth washes containing CHX 0.12% are used as a substitute for aqueous CHX 0.12% solution in laboratory experiments. Additionally, it is well known that for product flavor purposes, volatile compounds are added to mouth washes formulations. Volatiles added to CHX 0.12% may improve wash's antibacterial ability. Volatiles add potency to the mouth wash formulation. Compared with an aqueous CHX 0.12% solution, it is proposed that CHX solutions and Periogard<sup>®</sup> would have antimicrobial activity. Antimicrobial activity was assessed in the present study via disk diffusion assays against <italic>Streptococcus mutans</italic>, <italic>Streptococcus sanguinis</italic>and <italic>Escherichia coli</italic>. Periogard<sup>®</sup> showed a significantly higher antibacterial activity in relation to CHX 0.12% (p<0.05) and a similar activity in relation to CHX 1% (p>0.05). Periogard<sup>(r)</sup> volatiles were analyzed by gas-chromatography/mass spectrometry (GCMS) and the presence of antibacterial menthol, menthone, isomenthol, menthyl acetate, trans-anethol and eugenol was verified. Finally, the use of Periogard<sup>®</sup> as a synonym of CHX 0.12% must be avoided, because its antibacterial activity is closely related to CHX 1%.</p> (AU)