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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cytokines and Bone-Related Factors in Systemically Healthy Patients With Chronic Periodontitis and Patients With Type 2 Diabetes and Chronic Periodontitis

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Autor(es):
Ribeiro, Fernanda Vieira [1] ; de Mendonca, Adriana Cutrim [1] ; Santos, Vanessa Renata [1] ; Bastos, Marta Ferreira [1] ; Figueiredo, Luciene Cristina [1] ; Duarte, Poliana Mendes [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Journal of Periodontology; v. 82, n. 8, p. 1187-1196, AUG 2011.
Citações Web of Science: 53
Resumo

Background: This study compares the levels of cytokines and bone-related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better-controlled, and poorly controlled patients with type 2 diabetes and CP. Methods: Thirty-seven patients with type 2 diabetes and CP and 20 systemically healthy patients with CP were enrolled in this study. The patients with diabetes mellitus were categorized as better-controlled (n = 17; HbA(1c) levels <= 8%) or poorly controlled (n = 20; glycated hemoglobin values >8%). Levels of tumor necrosis factor-alpha, interleukin (IL)-4, interferon (IFN)-gamma, IL-23, IL-17, soluble receptor activator of nuclear factor-kappa B ligand (sRANKL), and osteoprotegerin (OPG) in GCF of diseased sites were analyzed by enzyme-linked immunosorbent assay. Results: Type 2 diabetes mellitus, as a whole, upregulates the levels of OPG, sRANKL, IFN-gamma, IL-17, and IL-23 and downregulates the production of IL-4 in sites with CP (P<0.05). Better-controlled individuals exhibited the highest levels of IFN-gamma, whereas poorly controlled patients presented the highest levels of IL-17 (P <0.05). There were no differences in the levels of tumor necrosis factor-a, OPG, and IL-23 among systemically healthy, better-controlled, and poorly controlled patients with diabetes (P>0.05). Conclusions: Increased levels of proinflammatory cytokines and RANKL were observed in the GCF of patients with type 2 diabetes with CP, compared to patients without diabetes. In addition, poor or good glycemic status seems to modulate osteo-immunoinflammatory mediators in a different manner. J Periodontol 2011;82:1187-1196. (AU)

Processo FAPESP: 08/09687-0 - Tratamento periodontal em indivíduos diabéticos compensados e não-compensados portadores de Diabetes Mellitus: avaliação clínica, glicêmica e dos níveis de citocinas e fatores de reabsorção óssea
Beneficiário:Poliana Mendes Duarte
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/04280-0 - Expressão gênica em sítios com periodontite crônica em indivíduos portadores de Diabetes Mellitus
Beneficiário:Poliana Mendes Duarte
Linha de fomento: Auxílio à Pesquisa - Regular