The Stem Cell Marker Bmi-1 Is Sensitive in Identifying Early Lesions of Carcinoma ex Pleomorphic Adenoma

Autor(es)

Sedassari, Bruno Tavares ^[1] ; Setubal Destro Rodrigues, Maria Fernanda ^[1] ; Mariano, Fernanda Viviane ^[2] ; Altemani, Albina ^[2] ; Nunes, Fabio Daumas ^[1] ; Sousa, Suzana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent, Dept Oral & Maxillofacial Pathol, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med, Dept Anat Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MEDICINE; v. 94, n. 27 JUL 2015.
• Citações Web of Science: 1

Resumo

In the present study, we evaluated and described the sensitivity of the stem cell marker B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) in identifying early lesions of carcinoma ex pleomorphic adenoma (CXPA). While invasive CXPAs are tumors with a prominent and easily recognizable malignant component, the identification of early carcinomatous changes in PA remains a diagnostic challenge due to the lack of objective morphological criteria. The immunohistochemical expression of Bmi-1 was assessed in both adenomatous and carcinomatous components of 9 CXPA cases at an early phase of histological progression (6 intracapsular and 3 minimally invasive) grouped according to the cellular differentiation as luminal (7 cases) or myoepithelial (2 cases). A selective nuclear expression of Bmi-1 was found exclusively in the malignant component of 8 cases (6 luminal type and 2 myoepithelial type), including intraductal carcinoma areas, except for 1 case in which scarce cells of the remnant PA were positive. Thus, Bmi-1 is expressed from the earliest morphologically detectable stages of PA malignant transformation. When faced with atypical features in PA, evaluation of Bmi-1 expression can provide more objective criteria for identification and diagnosis of early lesions of CXPA. This is applied to carcinomas with luminal or myoepithelial differentiation. (AU)

• Processo FAPESP: 12/00786-1 - Análise funcional da participação de vias de sinalização em células-tronco tumorais isoladas de linhagens celulares derivadas de carcinoma epidermóide bucal
• Beneficiário: Fabio Daumas Nunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular