| Texto completo | |
| Autor(es): |
Oliveira, Luanda M. S.
[1]
;
Lima, Josenilson F.
[1]
;
Cervantes, Cesar A. C.
[1]
;
Casseb, Jorge S.
[1, 2]
;
Mendonca, Marcelo
[3]
;
Duarte, Alberto J. S.
[1]
;
Sato, Maria N.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Dermatol, Trop Med Inst Sao Paulo, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ambulatory Serv, Secondary Immunodeficiency Clin, Clin Hosp, Med Sch, Sao Paulo - Brazil
[3] Emilio Ribas Infect Dis Inst Sao Paulo, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 5, SEP 8 2015. |
| Citações Web of Science: | 4 |
| Resumo | |
Some individuals are resistant to HIV-1 infection despite repeated exposure to the virus, suggesting the presence of a complex antiviral response. Innate factors like IL-22 exert gut mucosal protection and polyfunctional T cells have been associated with low progression in HIV infection; therefore, we evaluated the frequencies of CD4+ and CD8+ T cell-secreting cytokines, including Tc22/Th22 cells and polyfunctional T cells in HIV-1-exposed uninfected individuals (EUs), their HIV-1-infected partners and healthy controls. EUs exhibited an increased frequency of p15 Gag CD4+ IL-22+ secreting T cells, whereas HIV-infected partners demonstrated a high frequency of CD4+ IL-17+ T cells in response to p24. Similar responses of Th22 and Tc22 cells to Gag peptides and Staphylococcal enterotoxin B (SEB) stimulation were detected in the serodiscordant couples. However, polyfunctionality in HIV subjects was associated with an HIV Gag response of CD38+ T cells, whereas polyfunctionality for EUs was induced upon SEB stimulation by CD38-T cells. EUs demonstrated the presence of Tc22/Th22 cells and polyfunctional CD38-T cells with a low activation profile. These data suggest that SEB-induced polyfunctional CD4+ and CD8+ T cells together with Tc22/Th22 cells in EU individuals can provide an immunological advantage in the response to pathogens such as HIV-1. (AU) | |
| Processo FAPESP: | 15/00263-7 - Análise epigenetica dos genes envolvidos na resposta de interferon tipo I e perfil funcional de células da imunidade inata e adaptativa em casais sorodiscordantes para o HIV-1 |
| Beneficiário: | Maria Notomi Sato |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |