Increased frequency of circulating Tc22/Th22 cells and polyfunctional CD38(-) T cells in HIV-exposed uninfected subjects

Autor(es)

Oliveira, Luanda M. S. ^[1] ; Lima, Josenilson F. ^[1] ; Cervantes, Cesar A. C. ^[1] ; Casseb, Jorge S. ^{[1, 2]} ; Mendonca, Marcelo ^[3] ; Duarte, Alberto J. S. ^[1] ; Sato, Maria N. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Dermatol, Trop Med Inst Sao Paulo, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ambulatory Serv, Secondary Immunodeficiency Clin, Clin Hosp, Med Sch, Sao Paulo - Brazil

^[3] Emilio Ribas Infect Dis Inst Sao Paulo, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 5, SEP 8 2015.
• Citações Web of Science: 4

Resumo

Some individuals are resistant to HIV-1 infection despite repeated exposure to the virus, suggesting the presence of a complex antiviral response. Innate factors like IL-22 exert gut mucosal protection and polyfunctional T cells have been associated with low progression in HIV infection; therefore, we evaluated the frequencies of CD4+ and CD8+ T cell-secreting cytokines, including Tc22/Th22 cells and polyfunctional T cells in HIV-1-exposed uninfected individuals (EUs), their HIV-1-infected partners and healthy controls. EUs exhibited an increased frequency of p15 Gag CD4+ IL-22+ secreting T cells, whereas HIV-infected partners demonstrated a high frequency of CD4+ IL-17+ T cells in response to p24. Similar responses of Th22 and Tc22 cells to Gag peptides and Staphylococcal enterotoxin B (SEB) stimulation were detected in the serodiscordant couples. However, polyfunctionality in HIV subjects was associated with an HIV Gag response of CD38+ T cells, whereas polyfunctionality for EUs was induced upon SEB stimulation by CD38-T cells. EUs demonstrated the presence of Tc22/Th22 cells and polyfunctional CD38-T cells with a low activation profile. These data suggest that SEB-induced polyfunctional CD4+ and CD8+ T cells together with Tc22/Th22 cells in EU individuals can provide an immunological advantage in the response to pathogens such as HIV-1. (AU)

• Processo FAPESP: 15/00263-7 - Análise epigenética dos genes envolvidos na resposta de interferon tipo I e perfil funcional de células da imunidade inata e adaptativa em casais sorodiscordantes para o HIV-1
• Beneficiário: Maria Notomi Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular