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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased frequency of circulating Tc22/Th22 cells and polyfunctional CD38(-) T cells in HIV-exposed uninfected subjects

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Author(s):
Oliveira, Luanda M. S. [1] ; Lima, Josenilson F. [1] ; Cervantes, Cesar A. C. [1] ; Casseb, Jorge S. [1, 2] ; Mendonca, Marcelo [3] ; Duarte, Alberto J. S. [1] ; Sato, Maria N. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Dermatol, Trop Med Inst Sao Paulo, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ambulatory Serv, Secondary Immunodeficiency Clin, Clin Hosp, Med Sch, Sao Paulo - Brazil
[3] Emilio Ribas Infect Dis Inst Sao Paulo, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 5, SEP 8 2015.
Web of Science Citations: 4
Abstract

Some individuals are resistant to HIV-1 infection despite repeated exposure to the virus, suggesting the presence of a complex antiviral response. Innate factors like IL-22 exert gut mucosal protection and polyfunctional T cells have been associated with low progression in HIV infection; therefore, we evaluated the frequencies of CD4+ and CD8+ T cell-secreting cytokines, including Tc22/Th22 cells and polyfunctional T cells in HIV-1-exposed uninfected individuals (EUs), their HIV-1-infected partners and healthy controls. EUs exhibited an increased frequency of p15 Gag CD4+ IL-22+ secreting T cells, whereas HIV-infected partners demonstrated a high frequency of CD4+ IL-17+ T cells in response to p24. Similar responses of Th22 and Tc22 cells to Gag peptides and Staphylococcal enterotoxin B (SEB) stimulation were detected in the serodiscordant couples. However, polyfunctionality in HIV subjects was associated with an HIV Gag response of CD38+ T cells, whereas polyfunctionality for EUs was induced upon SEB stimulation by CD38-T cells. EUs demonstrated the presence of Tc22/Th22 cells and polyfunctional CD38-T cells with a low activation profile. These data suggest that SEB-induced polyfunctional CD4+ and CD8+ T cells together with Tc22/Th22 cells in EU individuals can provide an immunological advantage in the response to pathogens such as HIV-1. (AU)

FAPESP's process: 15/00263-7 - Epigenetic analysis of genes involved in type I interferon response and functional profile of cells from innate and adaptive immunity in serodiscordant couples for HIV-1
Grantee:Maria Notomi Sato
Support Opportunities: Regular Research Grants