| Texto completo | |
| Autor(es): Mostrar menos - |
Lopes, Junai C. S.
[1, 2]
;
Damasceno, Jaqueline L.
[3]
;
Oliveira, Pollyanna F.
[3]
;
Guedes, AdrianaP. M.
[4]
;
Tavares, Denise C.
[3]
;
Deflon, Victor M.
[5]
;
Lopes, Norberto P.
[6]
;
Pivatto, Marcos
[1]
;
Batista, Alzir A.
[4]
;
Maia, Pedro I. S.
[7]
;
Von Poelhsitz, Gustavo
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Univ Fed Uberlandia, Dept Quim, BR-38400902 Uberlandia, MG - Brazil
[2] Inst Fed Norte Minas Gerais, BR-39270000 Pirapora, MG - Brazil
[3] Univ Franca, BR-14404600 Franca, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Quim, BR-13561901 Sao Carlos, SP - Brazil
[5] Univ Fed Sao Carlos, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[6] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, NPPNS, BR-14040903 Ribeirao Preto, SP - Brazil
[7] Univ Fed Triangulo Mineiro, Inst Ciencias Nat Exatas & Educ, BR-38064200 Uberaba, MG - Brazil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 26, n. 9, p. 1838-1847, SEP 2015. |
| Citações Web of Science: | 11 |
| Resumo | |
The synthesis, characterization and cytotoxic activity of cis-[Ru(dicl)(dppm)2]PF6 and cis-[Ru(ibu)(dppm)2]PF6, (dppm = 1,1-bis(diphenylphosphine)methane; dicl = diclofenac anion and ibu = ibuprofen anion), are described in this work. Complexes were characterized by elemental analysis, Fourier transform infrared spectroscopy (FTIR), UV-Vis, 31P{1H} nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRESIMS). X-ray structure of cis-[Ru(ibu)(dppm)2]PF6 is also described. Preliminary calf thymus DNA (ct-DNA) binding studies were carried out by UV-Vis and viscosity experiments, with results suggesting the existence of electrostatic interactions between ruthenium complexes and ct-DNA. Cytotoxicity assays were carried out on a panel of human cancer cell lines and a human normal cell line. Complexes displayed a high to moderate cytotoxicity with IC50 ranging from 5 to 47 µmol L-1. cis-[Ru(ibu) (dppm)2]PF6 was found to be the most active, with IC50 values lower than cisplatin. The degree of cytotoxicity was maintained for the normal cell line, although cis-[Ru(ibu)(dppm)2]PF6 exhibited a similar selectivity to that of cisplatin but with a higher activity for at least two tumor cell lines which evidences a promising anticancer candidate and selects this complex for further experiments. (AU) | |
| Processo FAPESP: | 09/54011-8 - EMU: aquisição de difratômetro de raios X de monocristal para análise estrutural de moléculas pequenas e proteínas |
| Beneficiário: | Victor Marcelo Deflon |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |