Integrated approach in the assessment of skin compatibility of cosmetic formulations with green coffee oil

Autor(es)

Wagemaker, T. A. L. ^{[1, 2]} ; Rijo, P. ^[2] ; Rodrigues, L. M. ^{[2, 3]} ; Maia Campos, P. M. B. G. ^[1] ; Fernandes, A. S. ^[2] ; Rosado, C. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil

^[2] Univ Lusofona, Res Ctr Biosci & Hlth Technol, CBIOS, P-1749024 Lisbon - Portugal

^[3] Univ Lisbon, Sch Pharm, Dept Pharmacol Sci, P-1699 Lisbon - Portugal

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Cosmetic Science; v. 37, n. 5, p. 506-510, OCT 2015.
• Citações Web of Science: 9

Resumo

OBJECTIVE: Green coffee oil (GCO) has been used in cosmetic formulations due to its emollient and anti-ageing properties. However, there are insufficient studies about its safety when applied in cosmetic formulations. METHODS: Cytotoxicity of GCO and of formulations containing 2.5-15% of GCO was evaluated by the MTT reduction assay, in human keratinocytes. Formulations containing 15% of GCO and the vehicle were applied under in use conditions in the volar forearm of human volunteers during 3days. Transepidermal water loss, stratum corneum water content and erythema index were evaluated each 24h using biophysical techniques. The same formulations were probed for skin tolerance through a patch test. RESULTS: Neither pure GCO nor its formulations showed cytotoxic effects in concentrations up to 100g mL(-1). Transepidermal water loss values showed a slight reduction when the formulation containing GCO was applied. Stratum corneum water content and erythema index did not show significant differences, as the results observed in the first day of the study were maintained throughout 3days. None of the volunteers display any reaction after using an occlusive patch. CONCLUSION: The results obtained in the study indicate that GCO seems to be safe for topical applications and showed good skin compatibility under the experimental conditions of the study. (AU)

• Processo FAPESP: 12/02569-8 - Avaliação da segurança in vitro e in vivo de uma formulação cosmética contendo óleo de café
• Beneficiário: Tais Aleriana Lucon Wagemaker
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 09/14031-0 - Aplicação do óleo de café em formulações cosméticas: avaliação da estabilidade e da eficácia fotoprotetora
• Beneficiário: Tais Aleriana Lucon Wagemaker
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 07/53476-1 - Estudo da variabilidade do teor de oleoi e componentes da fracao lipidica do genero coffea visando usos alternativos para os graos.
• Beneficiário: Tais Aleriana Lucon Wagemaker
• Modalidade de apoio: Bolsas no Brasil - Mestrado