Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Integrated approach in the assessment of skin compatibility of cosmetic formulations with green coffee oil

Full text
Author(s):
Wagemaker, T. A. L. [1, 2] ; Rijo, P. [2] ; Rodrigues, L. M. [2, 3] ; Maia Campos, P. M. B. G. [1] ; Fernandes, A. S. [2] ; Rosado, C. [2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
[2] Univ Lusofona, Res Ctr Biosci & Hlth Technol, CBIOS, P-1749024 Lisbon - Portugal
[3] Univ Lisbon, Sch Pharm, Dept Pharmacol Sci, P-1699 Lisbon - Portugal
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Cosmetic Science; v. 37, n. 5, p. 506-510, OCT 2015.
Web of Science Citations: 9
Abstract

OBJECTIVE: Green coffee oil (GCO) has been used in cosmetic formulations due to its emollient and anti-ageing properties. However, there are insufficient studies about its safety when applied in cosmetic formulations. METHODS: Cytotoxicity of GCO and of formulations containing 2.5-15% of GCO was evaluated by the MTT reduction assay, in human keratinocytes. Formulations containing 15% of GCO and the vehicle were applied under in use conditions in the volar forearm of human volunteers during 3days. Transepidermal water loss, stratum corneum water content and erythema index were evaluated each 24h using biophysical techniques. The same formulations were probed for skin tolerance through a patch test. RESULTS: Neither pure GCO nor its formulations showed cytotoxic effects in concentrations up to 100g mL(-1). Transepidermal water loss values showed a slight reduction when the formulation containing GCO was applied. Stratum corneum water content and erythema index did not show significant differences, as the results observed in the first day of the study were maintained throughout 3days. None of the volunteers display any reaction after using an occlusive patch. CONCLUSION: The results obtained in the study indicate that GCO seems to be safe for topical applications and showed good skin compatibility under the experimental conditions of the study. (AU)

FAPESP's process: 12/02569-8 - In vitro and in vivo safety evaluation of cosmetic formulation containing coffee oil
Grantee:Tais Aleriana Lucon Wagemaker
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 09/14031-0 - Application of coffee oil in cosmetic formulations: evaluation of stability and effectiveness of sunscreen
Grantee:Tais Aleriana Lucon Wagemaker
Support Opportunities: Scholarships in Brazil - Doctorate