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Cosmetic permeation through human skin: theoretical and computational analysis

Grant number: 14/05975-2
Support type:Research Grants - Visiting Researcher Grant - International
Duration: February 23, 2015 - March 29, 2015
Field of knowledge:Engineering - Biomedical Engineering
Principal researcher:Airton Abrahao Martin
Grantee:Airton Abrahao Martin
Visiting researcher: Artur Cavaco-Paulo
Visiting researcher institution: Universidade do Minho (UMinho), Portugal
Home Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil

Abstract

We propose to develop applications of advanced molecular dynamics approaches at UNIVAP and University of Minho (Portugal).The confocal Raman and FTIR spectroscopy will be carried out at UNIVAP at Sao Jose dos Campos (Brazil) for chemical study of effects of cosmetic formulations on human skin. The research is based on a unique opportunity of bringing 2 leading research groups together that can elucidate mechanisms of interactions of cosmetic products with skin and elucidate possible absorption of components of such products into the skin. The theoretical skills and spectroscopic expertise of both groups in this area will be combined to achieve objectives of this project. The programme of work will explore applications of confocal Raman and FTIR spectra of skin samples in contact with cosmetic formulations to study in situ dynamic process of permeation of model formulations through the skin. A broader goal is to simulate permeation processes of the molecules revealing the underlying mechanisms of a possible adsorption or retention in the various layers of the skin. The combined application of experimental and theoretical approaches will provide a valuable database for cosmetic products design for skin treatment. The results of the research proposed here will contribute to the development of techniques for assessment of the risks and benefits associated with the topical application of cosmetic products and drugs, and for understanding the penetration pathways of exogenous chemicals through stratum corneum (SC), which is the uppermost layer of the skin. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACHADO, NEILA; BRUININKS, BART M. H.; SINGH, PRIYANKA; DOS SANTOS, LAURITA; DAL PIZZOL, CARINE; DIEAMANT, GUSTAVO DE C.; KRUGER, ODIVANIA; MARTIN, AIRTON A.; MARRINK, SIEWERT J.; SOUZA, PAULO C. T.; FAVERO, PRISCILA P. Complex nanoemulsion for vitamin delivery: droplet organization and interaction with skin membranes. NANOSCALE, v. 14, n. 2 NOV 2021. Web of Science Citations: 0.
MACHADO, NEILA; CARVALHO, B. G.; TELLEZ SOTO, C. A.; MARTIN, A. A.; FAVERO, P. P. DFT application for chlorin derivatives photosensitizer drugs modeling. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 195, p. 68-74, APR 15 2018. Web of Science Citations: 1.
DOS SANTOS, LAURITA; TELLEZ S, CLAUDIO A.; SOUSA, MARIANE P. J.; AZOIA, NUNO G.; CAVACO-PAULO, ARTUR M.; MARTIN, AIRTON A.; FAVERO, PRISCILA P. In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 174, p. 279-285, MAR 5 2017. Web of Science Citations: 7.
MACHADO, N. C. F.; DOS SANTOS, L.; CARVALHO, B. G.; SINGH, P.; TELLEZ SOTO, C. A.; AZOIA, N. G.; CAVACO-PAULO, A.; MARTIN, A. A.; FAVERO, P. P. Assessment of penetration of Ascorbyl Tetraisopalmitate into biological membranes by molecular dynamics. COMPUTERS IN BIOLOGY AND MEDICINE, v. 75, p. 151-159, AUG 1 2016. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.