Splenic macrophage subsets and their function during blood-borne infections

Autor(es)

da Silva, Henrique Borges ^[1] ; Fonseca, Raissa ^[1] ; Pereira, Rosana Moreira ^[1] ; Cassado, Alexandra dos Anjos ^[1] ; Alvarez, Jose Maria ^[1] ; D'Imperio Lima, Maria Regina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Immunol, Inst Ciencias Biomed, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 6, SEP 22 2015.
• Citações Web of Science: 38

Resumo

The spleen is one of the major immunological sites for maintaining blood homeostasis. Previous studies showed that heterogeneous splenic macrophage populations contribute in complimentary ways to control blood-borne infections and induce effective immune responses. Marginal metallophilic macrophages (MMM Phi s) and marginal zone macrophages (MZM Phi s) are cells with great ability to internalize blood-borne pathogens such as virus or bacteria. Their localization adjacent to T- and B-cell-rich splenic areas favors the rapid contact between these macrophages and cells from adaptive immunity. Indeed, MMM Phi s and MZM Phi s are considered important bridges between innate and adaptive immunity. Although red pulp macrophages (RpM Phi s) are mainly considered scavengers for senescent erythrocytes, several data indicate a role for RpM Phi s in control of infections such as blood-stage malaria as well as in the induction of innate and adaptive immunity. Here, we review current data on how different macrophage subsets recognize and help eliminate blood-borne pathogens, and, in turn, how the inflammatory microenvironment in different phases of infection (acute, chronic, and after pathogen clearance) influences macrophage function and survival. (AU)

• Processo FAPESP: 14/00810-5 - Priming por IFN-gama durante a fase crônica da malária experimental: estudo dos mecanismos moleculares e efetores envolvidos
• Beneficiário: Henrique Borges da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07140-2 - Papel dos inflamassomas na patogenia da tuberculose causada por isolados clínicos hipervirulentos de micobactérias
• Beneficiário: Maria Regina D'Império Lima
• Modalidade de apoio: Auxílio à Pesquisa - Regular