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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Splenic macrophage subsets and their function during blood-borne infections

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Author(s):
da Silva, Henrique Borges [1] ; Fonseca, Raissa [1] ; Pereira, Rosana Moreira [1] ; Cassado, Alexandra dos Anjos [1] ; Alvarez, Jose Maria [1] ; D'Imperio Lima, Maria Regina [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Immunol, Inst Ciencias Biomed, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: FRONTIERS IN IMMUNOLOGY; v. 6, SEP 22 2015.
Web of Science Citations: 39
Abstract

The spleen is one of the major immunological sites for maintaining blood homeostasis. Previous studies showed that heterogeneous splenic macrophage populations contribute in complimentary ways to control blood-borne infections and induce effective immune responses. Marginal metallophilic macrophages (MMM Phi s) and marginal zone macrophages (MZM Phi s) are cells with great ability to internalize blood-borne pathogens such as virus or bacteria. Their localization adjacent to T- and B-cell-rich splenic areas favors the rapid contact between these macrophages and cells from adaptive immunity. Indeed, MMM Phi s and MZM Phi s are considered important bridges between innate and adaptive immunity. Although red pulp macrophages (RpM Phi s) are mainly considered scavengers for senescent erythrocytes, several data indicate a role for RpM Phi s in control of infections such as blood-stage malaria as well as in the induction of innate and adaptive immunity. Here, we review current data on how different macrophage subsets recognize and help eliminate blood-borne pathogens, and, in turn, how the inflammatory microenvironment in different phases of infection (acute, chronic, and after pathogen clearance) influences macrophage function and survival. (AU)

FAPESP's process: 14/00810-5 - IFN-gamma-induced priming during chronic experimental malaria: study of the molecular and effector mechanisms involved
Grantee:Henrique Borges da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07140-2 - Role of inflammasomas in the pathogenesis of tuberculosis caused by hypervirulent clinical isolates of mycobacteria
Grantee:Maria Regina D'Império Lima
Support type: Regular Research Grants