Quantitative analysis of mebendazole polymorphs in pharmaceutical raw materials using near-infrared spectroscopy

Autor(es)

da Silva, Vitor H. ^[1] ; Goncalves, Jacqueline L. ^[2] ; Vasconcelos, Fernanda V. C. ^[3] ; Pimentel, M. Fernanda ^[4] ; Pereira, Claudete F. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Rural Pernambuco, Dept Quim, UFRPE, BR-52071030 Recife, PE - Brazil

^[2] Univ Fed Pernambuco, Dept Quim Fundamental, UFPE, BR-50740560 Recife, PE - Brazil

^[3] Univ Fed Paraiba, Dept Quim, UFPE, BR-58051970 Joao Pessoa, Paraiba - Brazil

^[4] Univ Fed Pernambuco, Dept Engn Quim, Lab Combustiveis LAC, UFPE, BR-50740521 Recife, PE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Pharmaceutical and Biomedical Analysis; v. 115, p. 587-593, NOV 10 2015.
• Citações Web of Science: 5

Resumo

This work evaluates the feasibility of using NIR spectroscopy for quantification of three polymorphs of mebendazole (MBZ) in pharmaceutical raw materials. Thirty ternary mixtures of polymorphic forms of MBZ were prepared, varying the content of forms A and C from 0 to 100% (w/w), and for form B from 0 to 30% (w/w). Reflectance NIR spectra were used to develop partial least square (PLS) regression models using all spectral variables and the variables with significant regression coefficients selected by the Jack-Knife algorithm (PLS/JK). MBZ polymorphs were quantified with RMSEP values of 2.37% w/w, 1.23% w/w and 1.48% w/w for polymorphs A, B and C, respectively. This is an easy, fast and feasible method for monitoring the quality of raw pharmaceutical materials of MBZ according to polymorph purity. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 08/57808-1 - Instituto Nacional de Ciências e Tecnologias Analíticas Avançadas - INCTAA
• Beneficiário: Celio Pasquini
• Modalidade de apoio: Auxílio à Pesquisa - Temático