Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

Autor(es):Mostrar menos -

da Silva, Cristiana ^[1] ; Ribeiro, Leonardo B. ^[1] ; Furuno, Caio C. ^[1] ; da Cunha, Gislaine A. ^[1] ; de Souza, Ronan F. F. ^[1] ; Netto, Adelino V. G. ^[1] ; Mauro, Antonio E. ^[1] ; Frem, Regina C. G. ^[1] ; Fernandes, Jose A. ^[2] ; Almeida Paz, Filipe A. ^[2] ; Marino, Leonardo B. ^[3] ; Pavan, Fernando R. ^[3] ; Leite, Clarice Q. F. ^[3]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP - Brazil

^[2] Univ Aveiro, CICECO, Dept Chem, Campus Univ Santiago, P-3810193 Aveiro - Portugal

^[3] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, BR-14801970 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Polyhedron; v. 100, p. 10-16, NOV 4 2015.
• Citações Web of Science: 5

Resumo

Complexes of the type trans-{[}PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/15486-3 - Compostos de Pd(II): síntese, citotoxicidade e investigação espectrofotométrica da interação com o DNA
• Beneficiário: Regina Celia Galvao Frem
• Modalidade de apoio: Auxílio à Pesquisa - Regular