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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

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Author(s):
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da Silva, Cristiana [1] ; Ribeiro, Leonardo B. [1] ; Furuno, Caio C. [1] ; da Cunha, Gislaine A. [1] ; de Souza, Ronan F. F. [1] ; Netto, Adelino V. G. [1] ; Mauro, Antonio E. [1] ; Frem, Regina C. G. [1] ; Fernandes, Jose A. [2] ; Almeida Paz, Filipe A. [2] ; Marino, Leonardo B. [3] ; Pavan, Fernando R. [3] ; Leite, Clarice Q. F. [3]
Total Authors: 13
Affiliation:
[1] UNESP Univ Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP - Brazil
[2] Univ Aveiro, CICECO, Dept Chem, Campus Univ Santiago, P-3810193 Aveiro - Portugal
[3] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, BR-14801970 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Polyhedron; v. 100, p. 10-16, NOV 4 2015.
Web of Science Citations: 5
Abstract

Complexes of the type trans-{[}PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/15486-3 - Pd(II) compounds: synthesis, cytotoxicity, and DNA binding studies
Grantee:Regina Celia Galvao Frem
Support Opportunities: Regular Research Grants