The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats

Autor(es)

Trindade Fortaleza, Eduardo Albino ^[1] ; Ferreira-Junior, Nilson Carlos ^[1] ; Lagatta, Davi Campos ^[1] ; Moraes Resstel, Leonardo Barbosa ^[1] ; Aguiar Correa, Fernando Morgan ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14090090 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 193, p. 44-50, DEC 2015.
• Citações Web of Science: 4

Resumo

The medial amygdaloid nucleus (MeA) is involved in cardiovascular control. In the present study we report the effect of MeA pharmacological ablations caused by bilateral microinjections of the nonselective synaptic blocker CoCl2 on cardiac baroreflex responses in rats. MeA synaptic inhibition evoked by local bilateral microinjection of 100 nL of CoCl2 (1 mM) did not affect blood pressure or heart rate baseline, suggesting no tonic MeA influence on resting cardiovascular parameters. However, 10 min after CoCl2 microinjection into the MeA of male Wistar rats, the reflex bradycardic response evoked by intravenous infusion of phenylephrine was significantly enhanced when compared with the reflex bradycardic response observed before CoCl2. The treatment did not affect the tachycardic responses to the intravenous infusion of sodium nitroprusside (SNP). Baroreflex activity returned to control values 60 min after CoCl2 microinjections, confirming a reversible blockade. The present results indicate an involvement of the MeA in baroreflex modulation, suggesting that synapses in the MeA have an inhibitory influence on the bradycardic component of the baroreflex in conscious rats. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/18556-2 - Envolvimento do sistema glutamatérgico dos núcleos paraventricular e supra-óptico na modulação do sistema cardiovascular e na liberação de vasopressina e ocitocina em ratos submetidos ao estímulo osmótico.
• Beneficiário: Eduardo Albino Trindade Fortaleza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/19494-8 - Envolvimento do hipocampo dorsal na modulação da atividade barorreflexa cardíaca: participação dos receptores NMDA, CB1, TRPV1, muscarínicos e do óxido nítrico.
• Beneficiário: Nilson Carlos Ferreira Junior
• Modalidade de apoio: Bolsas no Brasil - Doutorado