Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine

Autor(es)

de Araujo, Adriana Ladeira ^[1] ; Rodrigues Silva, Leia Cristina ^[1] ; Fernandes, Juliana Ruiz ^[1] ; Toledo Matias, Manuella de Sousa ^[2] ; Boas, Lucy Santos ^[3] ; Machado, Clarisse Martins ^[3] ; Garcez-Leme, Luiz Eugenio ^[2] ; Benard, Gil ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Clin Hosp, Div Dermatol, Lab Dermatol & Immunodeficiencies, BR-05403903 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Orthoped & Traumatol, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Trop Med, Virol Lab, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Trop Med, Med Mycol Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AGE; v. 37, n. 6 DEC 2015.
• Citações Web of Science: 10

Resumo

We aimed to verify whether different levels of training performed regularly and voluntarily for many years could have an impact on one of the main issues of immunosenescence: the poor response to vaccines. We recruited 61 healthy elderly men (65-85 years old), 23 with a moderate training (MT) lifestyle (for 17.0 +/- 3.2 years), 22 with an intense training (IT) lifestyle (for 25.9 +/- 3.4 years), and 16 without a training lifestyle (NT). Fitness was evaluated through the IPAQ and VO2max consumption. The participants were evaluated regarding cognitive aspects, nutritional status, depression, and quality of life. Antibody titers were determined by hemagglutination inhibition assay prior to influenza vaccination and at 6 weeks and 6 months post-vaccination. Strains used were B, H3N2, and H1N1. Our groups were matched for most characteristics, except for those directly influenced by their lifestyles, such as BMI, VO(2)max, and MET. In general, MT and IT elderly men showed significantly higher antibody titers to the three vaccine strains post-vaccination than NT elderly men. There were also higher titers against B and H1N1 strains in the trained groups before vaccination. Additionally, there were higher proportions of seroprotected (titers >= 1:40) individuals in the pooled trained groups both at 6 weeks (B and H3N2, p<0.05) and 6 months (H1N1, p<0.05; B, p=0.07). There were no significant differences between the MT and IT groups. Either a moderate or an intense training is associated with stronger and longstanding antibody responses to the influenza vaccine, resulting in higher percentages of seroprotected individuals. (AU)

• Processo FAPESP: 11/18268-4 - Impacto da prática da atividade física moderada regular no retardo da imunossenescência de idosos
• Beneficiário: Léia Cristina Rodrigues da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/08817-0 - Efeito da atividade física de alto desempenho aeróbico regular na resposta imune e no encurtamento do telômero em linfócitos T de idosos
• Beneficiário: Gil Benard
• Modalidade de apoio: Auxílio à Pesquisa - Regular