``Photo{''} Chemistry Without Light?

Autor(es)

Baader, Wilhelm J. ^[1] ; Stevani, Cassius V. ^[1] ; Bechara, Etelvino J. H. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of the Brazilian Chemical Society; v. 26, n. 12, p. 2430-2447, DEC 2015.
• Citações Web of Science: 8

Resumo

In the early seventies, Giuseppe Cilento (Sao Paulo University), Emil White (Johns Hopkins University) and Angelo Lamola (AT\&T Bell Laboratories) postulated that typical photochemical reactions could occur in dark parts of living organisms if coupled to enzymatic sources of electronically excited products. Their paradoxical hypothesis of ``photochemistry without light{''} was chemically anchored on the synthesis and weak chemiluminescence of several 1,2-dioxetanes, unstable cyclic peroxides whose thermal cleavage produces long-lived and reactive triplet carbonyls. Collisional reactions or energy transfer of triplet species to cellular targets could eventually result in ``photo{''} products that potentially trigger normal or pathological responses. These ideas flourished in the labs of various researchers who attempted to explain the presence and biological roles of ``dark{''} secondary metabolites, including plant hormones, pyrimidine dimers, alkaloid lumi-isomers, protein adducts, and mitochondrial permeators, thereby broadening the field of photobiology. (AU)

• Processo FAPESP: 06/56530-4 - Estresse redox e carbonílico associado a alfa-aminocetonas e beta-cetoácidos endógenos: mecanismos e biomarcadores
• Beneficiário: Etelvino José Henriques Bechara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 08/57721-3 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/16885-1 - Bioluminescência em fungos: levantamento de espécies, estudo mecanístico & ensaios toxicológicos
• Beneficiário: Cassius Vinicius Stevani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/22136-4 - Uso de solventes verdes e suas misturas na otimização de processos químicos
• Beneficiário: Omar Abou El Seoud
• Modalidade de apoio: Auxílio à Pesquisa - Temático