Response surface methodology applied to the study of the microwave-assisted synthesis of quaternized chitosan

Autor(es)

dos Santos, Danilo Martins ^[1] ; Bukzem, Andrea de Lacerda ^[1] ; Campana-Filho, Sergio Paulo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Carbohydrate Polymers; v. 138, p. 317-326, MAR 15 2016.
• Citações Web of Science: 10

Resumo

A quaternized derivative of chitosan, namely N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh), was synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) and chitosan (Ch) in acid medium under microwave irradiation. Full-factorial 2(3) central composite design and response surface methodology (RSM) were applied to evaluate the effects of molar ratio GTMAC/Ch, reaction time and temperature on the reaction yield, average degree of quaternization ((DQ) over bar) and intrinsic viscosity ({[}eta]) of QCh. The molar ratio GTMAC/Ch was the most important factor affecting the response variables and RSM results showed that highly substituted QCh ((DQ) over bar = 71.1%) was produced at high yield (164%) when the reaction was carried out for 30 min. at 85 degrees C by using molar ratio GTMAC/Ch 611. Results showed that microwave-assisted synthesis is much faster (<= 30 min.) as compared to conventional reaction procedures (>4 h) carried out in similar conditions except for the use of microwave irradiation. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/02526-1 - Estudos dos efeitos da irradiação de ultrassom de alta intensidade em suspensões aquosas de quitina e quitosana
• Beneficiário: Sérgio Paulo Campana Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular