Response surface methodology applied to the study of the microwave-assisted synthesis of quaternized chitosan

Author(s)

dos Santos, Danilo Martins ^[1] ; Bukzem, Andrea de Lacerda ^[1] ; Campana-Filho, Sergio Paulo ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Carbohydrate Polymers; v. 138, p. 317-326, MAR 15 2016.
• Web of Science Citations: 10

Abstract

A quaternized derivative of chitosan, namely N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh), was synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) and chitosan (Ch) in acid medium under microwave irradiation. Full-factorial 2(3) central composite design and response surface methodology (RSM) were applied to evaluate the effects of molar ratio GTMAC/Ch, reaction time and temperature on the reaction yield, average degree of quaternization ((DQ) over bar) and intrinsic viscosity ({[}eta]) of QCh. The molar ratio GTMAC/Ch was the most important factor affecting the response variables and RSM results showed that highly substituted QCh ((DQ) over bar = 71.1%) was produced at high yield (164%) when the reaction was carried out for 30 min. at 85 degrees C by using molar ratio GTMAC/Ch 611. Results showed that microwave-assisted synthesis is much faster (<= 30 min.) as compared to conventional reaction procedures (>4 h) carried out in similar conditions except for the use of microwave irradiation. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 10/02526-1 - Studies on the effects of the high intensity ultrasound irradiation on the aqueous suspensions of chitin and chitosan
• Grantee: Sérgio Paulo Campana Filho
• Support Opportunities: Regular Research Grants