| Texto completo | |
| Autor(es): |
Merlo, Suelen
[1]
;
Nakayama, Ana Beatriz S.
[1]
;
Brusco, Janaina
[1]
;
Rossi, Marcos A.
[2]
;
Carlotti, Jr., Carlos G.
[3]
;
Moreira, Jorge E.
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol & Forens Med, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Surg & Anat, BR-14049 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ULTRASTRUCTURAL PATHOLOGY; v. 39, n. 6, p. 378-384, NOV 2 2015. |
| Citações Web of Science: | 2 |
| Resumo | |
Lipofuscin granules (LGs), the age pigments, are autofluorescent cell products from lysosomes that diverge in number and size among brain regions. Human temporal cortex from 20- to 55-year-old epileptic subjects were studied with the fat soluble dye Sudan Black, under confocal and electron microscopy. Ultrastructural analysis showed that with age LGs increase in area, but not in number. Proportionally to the LGs area, the electron lucid portion increases and the electron dense reduces over time. The robust increase in lipid components is possibly due to modifications in the neuronal metabolism with age in physiological and pathological conditions. (AU) | |
| Processo FAPESP: | 12/19011-0 - Estudo dos espinhos dendríticos na amígdala medial póstero-dorsal de ratos: morfologia e conectividade |
| Beneficiário: | Jorge Eduardo Moreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |