| Full text | |
| Author(s): |
Merlo, Suelen
[1]
;
Nakayama, Ana Beatriz S.
[1]
;
Brusco, Janaina
[1]
;
Rossi, Marcos A.
[2]
;
Carlotti, Jr., Carlos G.
[3]
;
Moreira, Jorge E.
[1, 2]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pathol & Forens Med, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Surg & Anat, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ULTRASTRUCTURAL PATHOLOGY; v. 39, n. 6, p. 378-384, NOV 2 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
Lipofuscin granules (LGs), the age pigments, are autofluorescent cell products from lysosomes that diverge in number and size among brain regions. Human temporal cortex from 20- to 55-year-old epileptic subjects were studied with the fat soluble dye Sudan Black, under confocal and electron microscopy. Ultrastructural analysis showed that with age LGs increase in area, but not in number. Proportionally to the LGs area, the electron lucid portion increases and the electron dense reduces over time. The robust increase in lipid components is possibly due to modifications in the neuronal metabolism with age in physiological and pathological conditions. (AU) | |
| FAPESP's process: | 12/19011-0 - Dendritic spines in the posterodorsal medial amygdala of rats: morphology and connectivity |
| Grantee: | Jorge Eduardo Moreira |
| Support Opportunities: | Regular Research Grants |