A spring to summer shift of pro-inflammatory cytokine production in multiple sclerosis patients

Autor(es)

Damasceno, Alfredo ^{[1, 2]} ; Moraes, Adriel Santos ^[2] ; Farias, Alessandro ^[2] ; Damasceno, Benito Pereira ^[1] ; Barbosa dos Santos, Leonilda Maria ^[2] ; Cendes, Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Neurol, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Neuroimmunol Unit, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE NEUROLOGICAL SCIENCES; v. 360, p. 37-40, JAN 15 2016.
• Citações Web of Science: 3

Resumo

Higher MS relapse frequency is observed during warmer months in different regions, but evidence for an underlying immunological variation is lacking. Therefore, we investigated seasonal variations of cytokine production in relapsing-remitting MS patients. Twenty-one patients and eight controls had blood samples drawn in each season, evaluating for IL-10, IL-6, TNF-alpha and IFN-gamma. The lowest levels of cytokine production were observed in spring samples, with a significant increase from spring to summer for most cytokines, and especially IFN-gamma and TNF-alpha. This phenomenon may underlie the higher prevalence of clinical and subclinical MS activity observed in warmer months. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 10/00885-4 - Avaliação longitudinal da atrofia cerebral e espessura cortical e sua relação com fatores clínicos e imunológicos em pacientes com esclerose múltipla
• Beneficiário: Alfredo Damasceno
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto