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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A spring to summer shift of pro-inflammatory cytokine production in multiple sclerosis patients

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Damasceno, Alfredo [1, 2] ; Moraes, Adriel Santos [2] ; Farias, Alessandro [2] ; Damasceno, Benito Pereira [1] ; Barbosa dos Santos, Leonilda Maria [2] ; Cendes, Fernando [1]
Total Authors: 6
[1] Univ Estadual Campinas, Dept Neurol, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Neuroimmunol Unit, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF THE NEUROLOGICAL SCIENCES; v. 360, p. 37-40, JAN 15 2016.
Web of Science Citations: 3

Higher MS relapse frequency is observed during warmer months in different regions, but evidence for an underlying immunological variation is lacking. Therefore, we investigated seasonal variations of cytokine production in relapsing-remitting MS patients. Twenty-one patients and eight controls had blood samples drawn in each season, evaluating for IL-10, IL-6, TNF-alpha and IFN-gamma. The lowest levels of cytokine production were observed in spring samples, with a significant increase from spring to summer for most cytokines, and especially IFN-gamma and TNF-alpha. This phenomenon may underlie the higher prevalence of clinical and subclinical MS activity observed in warmer months. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 10/00885-4 - Longitudinal evaluation of cerebral atrophy and cortical thickness and its relationship with clinical and immunological factors in patients with multiple sclerosis
Grantee:Alfredo Damasceno
Support type: Scholarships in Brazil - Doctorate (Direct)