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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three-Month Randomized Clinical Trial

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Autor(es):
Raslan, Suzane A. [1] ; Cortelli, Jose R. [2] ; Costa, Fernando O. [3] ; Aquino, Davi R. [2] ; Franco, Gilson C. N. [4] ; Cota, Luis O. M. [3] ; Gargioni-Filho, Antonio [1] ; Cortelli, Sheila C. [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Taubate, Sch Dent, Sao Paulo - Brazil
[2] Univ Taubate, Ctr Periodontal Res, Taubate, SP - Brazil
[3] Univ Fed Minas Gerais, Sch Dent, Belo Horizonte, MG - Brazil
[4] Univ Estadual Ponta Grossa, Sch Dent, Ponta Grossa, Parana - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Periodontology; v. 86, n. 4, p. 516-526, APR 2015.
Citações Web of Science: 1
Resumo

Background: Although patients with diabetes are frequently affected by periodontitis, only a few investigations have focused on gingivitis in this at-risk population. This randomized placebo-controlled clinical trial compared the response to a gingivitis treatment protocol that combined mechanical procedures and daily use of an essential oil (EO) mouthrinse between patients with and without diabetes. Methods: The whole-mouth periodontal probing depth (PD), gingival index (GI), and plaque index (PI) were monitored in gingivitis cases among systemically healthy patients (n = 60) or those with diabetes (n = 60) at baseline and 3 months after treatment. Levels of Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and total bacterial load were determined by a real-time polymerase chain reaction in intrasulci plaque samples. The volume of gingival crevicular fluid (GCF) was quantified, and interleukin-1 beta (IL-1 beta) levels were determined in GCF samples. After a full-mouth ultrasonic debridement, patients were randomly assigned to an EO or a placebo rinse for 90 days (40 mL/day). The data were analyzed through repeated-measures analysis of variance and multiple comparisons Tukey tests (P <0.05). Results: GI was more severe in the diabetes group. Diabetes impaired GI and reduced GCF volume. PD, bacterial levels, and IL-1 beta improved similarly in both systemic conditions. The adjunctive use of EO provided greater reductions of PI, GI, total bacterial load, T. forsythia, A. actinomycetemcomitans, and GCF volume. Conclusions: Response to gingivitis treatment in patients with diabetes can slightly differ from that in patients without diabetes. Daily use of an EO mouthrinse after ultrasonic debridement benefited patients with and without diabetes. (AU)

Processo FAPESP: 10/20424-1 - Avaliação da terapia gengival mecânico-química em indivíduos com diabetes, obesidade ou diabesidade: análises quantitativas e qualitativas de aspectos locais e gerais
Beneficiário:Sheila Cavalca Cortelli
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/02371-0 - Avaliação da terapia gengival em indivíduos com diabetes, obesidade ou diabesidade
Beneficiário:Suzane A Raslan
Modalidade de apoio: Bolsas no Brasil - Doutorado