| Texto completo | |
| Autor(es): |
Shang, Zhuo
[1]
;
Li, Li
[2, 3]
;
Esposito, Breno P.
[4]
;
Salim, Angela A.
[1]
;
Khalil, Zeinab G.
[1]
;
Quezada, Michelle
[1]
;
Bernhardt, Paul V.
[5]
;
Capon, Robert J.
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072 - Australia
[2] Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Druggabil E, Beijing 100050 - Peoples R China
[3] Peking Union Med Coll, Beijing 100050 - Peoples R China
[4] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo - Brazil
[5] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072 - Australia
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORGANIC & BIOMOLECULAR CHEMISTRY; v. 13, n. 28, p. 7795-7802, 2015. |
| Citações Web of Science: | 14 |
| Resumo | |
Chemical analysis of a marine-derived fungus, Chaunopycnis sp. (CMB-MF028), isolated from the inner tissue of a pulmonate false limpet Siphonaria sp., collected from rock surfaces in the intertidal zone of Moora Park, Shorncliffe, Queensland, yielded the tetramic acid F-14329 (1) and new analogues, chaunolidines A-C (2-4), together with the new pyridinone chaunolidone A (5), and pyridoxatin (6). Structures inclusive of absolute configurations were assigned to 1-6 on the basis of detailed spectroscopic analysis, X-ray crystallography, electronic circular dichroism (ECD), biosynthetic considerations and chemical inter-conversion. Chaunolidine C (4) exhibits modest Gram-positive antibacterial activity (IC50 5-10 mu M), while chaunolidone A (5) is a selective and potent inhibitor (IC50 0.09 mu M) of human non-small cell lung carcinoma cells (NCI-H460). Tetramic acids 1-4 form metal chelates with Fe(III), Al(III), Cu(II), Mg(II) and Zn(II). (AU) | |
| Processo FAPESP: | 13/13166-4 - Bioprospecção de sideróforos marinhos com vistas à terapia de quelação de sobrecarga de ferro |
| Beneficiário: | Breno Pannia Esposito |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |