Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release

Autor(es)

Rocha, Michele A. ^[1] ; Petersen, Philippe A. D. ^[2] ; Teixeira-Neto, Erico ^[3] ; Petrilli, Helena M. ^[2] ; Leroux, Fabrice ^{[4, 5]} ; Taviot-Gueho, Christine ^{[4, 5]} ; Constantino, Vera R. L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, CP 26077, BR-05513970 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Fis, CP 66318, BR-05315970 Sao Paulo, SP - Brazil

^[3] CNPEM, Lab Nacl Nanotecnol, CP 6192, BR-13083970 Campinas, SP - Brazil

^[4] Univ Clermont Ferrand, Univ Clermont Auvergne, Inst Chim Clermont Ferrand, BP 10448, F-63000 Clermont Ferrand - France

^[5] CNRS, ICCF, UMR 6296, F-63178 Aubiere - France

• Tipo de documento: Artigo Científico
• Fonte: RSC ADVANCES; v. 6, n. 20, p. 16419-16436, 2016.
• Citações Web of Science: 20

Resumo

Sulindac, a non-steroidal anti-inflammatory of the indene acetic acid class, was immobilized inside layered double hydroxide Mg2Al and Zn2Al (LDH) nanovessels through a one pot reaction. LDH-drug materials were characterized by chemical elemental analysis, X-ray diffraction (XRD) (one dimensional electron distribution along the c-stacking axis, pair distribution function analysis), scanning and transmission electron microscopies, mass coupled thermal analyses, vibrational infrared and Raman spectroscopies, and solid state C-13 NMR. Density Functional Theory (DFT) calculations were performed for sulindac (protonated and deprotonated forms) with the aim to assign the LDH-drug spectroscopic results. All converge towards a spatial organization of interleaved sulindac molecules close to that reported for the pristine polymorph II crystal structure. Of relevance for human treatment because of its biocompatibility and non-immunogenic effect, in vitro sulindac release experiments were performed in a phosphate buffer mimicking biological fluids and release profiles were refined using kinetic models. (AU)

• Processo FAPESP: 11/50318-1 - Desenvolvimento de compostos com interesse farmacológico ou medicinal e de sistemas para seu transporte, detecção e reconhecimento no meio biológico
• Beneficiário: Ana Maria da Costa Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático