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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release

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Author(s):
Rocha, Michele A. [1] ; Petersen, Philippe A. D. [2] ; Teixeira-Neto, Erico [3] ; Petrilli, Helena M. [2] ; Leroux, Fabrice [4, 5] ; Taviot-Gueho, Christine [4, 5] ; Constantino, Vera R. L. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, CP 26077, BR-05513970 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Fis, CP 66318, BR-05315970 Sao Paulo, SP - Brazil
[3] CNPEM, Lab Nacl Nanotecnol, CP 6192, BR-13083970 Campinas, SP - Brazil
[4] Univ Clermont Ferrand, Univ Clermont Auvergne, Inst Chim Clermont Ferrand, BP 10448, F-63000 Clermont Ferrand - France
[5] CNRS, ICCF, UMR 6296, F-63178 Aubiere - France
Total Affiliations: 5
Document type: Journal article
Source: RSC ADVANCES; v. 6, n. 20, p. 16419-16436, 2016.
Web of Science Citations: 20
Abstract

Sulindac, a non-steroidal anti-inflammatory of the indene acetic acid class, was immobilized inside layered double hydroxide Mg2Al and Zn2Al (LDH) nanovessels through a one pot reaction. LDH-drug materials were characterized by chemical elemental analysis, X-ray diffraction (XRD) (one dimensional electron distribution along the c-stacking axis, pair distribution function analysis), scanning and transmission electron microscopies, mass coupled thermal analyses, vibrational infrared and Raman spectroscopies, and solid state C-13 NMR. Density Functional Theory (DFT) calculations were performed for sulindac (protonated and deprotonated forms) with the aim to assign the LDH-drug spectroscopic results. All converge towards a spatial organization of interleaved sulindac molecules close to that reported for the pristine polymorph II crystal structure. Of relevance for human treatment because of its biocompatibility and non-immunogenic effect, in vitro sulindac release experiments were performed in a phosphate buffer mimicking biological fluids and release profiles were refined using kinetic models. (AU)

FAPESP's process: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media
Grantee:Ana Maria da Costa Ferreira
Support Opportunities: Research Projects - Thematic Grants