Advanced search
Start date
Betweenand

Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media

Grant number: 11/50318-1
Support type:Research Projects - Thematic Grants
Duration: September 01, 2011 - November 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Ana Maria da Costa Ferreira
Grantee:Ana Maria da Costa Ferreira
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Helena Maria Petrilli ; Vera Regina Leopoldo Constantino
Associated grant(s):16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release, AP.R SPRINT
14/09367-7 - Investigation on the role of metallodrug-carbohydrate interactions in multidrug resistance tumor cells, AV.EXT
Associated scholarship(s):12/22067-7 - Development of electronic and structural biomolecular models for pharmaceutical and medicinal applications, BP.PD
12/24637-5 - Studies on interactions of essential metal complexes and proteasome, BP.IC
12/17671-2 - Investigations on the Biological Activity of Heterodinuclear Complexes based on Copper and Platinum, BP.PD
+ associated scholarships 12/12209-9 - Inorganic carriers of bioactive substances: development, characterization, toxicity evaluation of in vitro delivery and in vivo absorption after oral administration, BP.PD
11/18958-0 - Chelator-peptide conjugates permeable to the blood-brain barrier as protectors against iron-induced toxicity, BP.PD
12/06291-4 - Synthesis and characterization of hybrid materials based on layered double hydroxides and bioactive organic species, BP.IC
12/02326-8 - Computational modeling of solid-molecule interaction in systems with nanotechnology interests, BP.DR - associated scholarships

Abstract

Studies of reactive species in biological systems, implicated in vital or pathological processes are focused in this project. The design, preparation and isolation of those species as free compounds or inserted in suitable inorganic matrices, forming functional materials will be provided. Those species include antioxidant or oxidant compounds, polymers, chelating agents, and respective metal complexes. Their reactivity in processes, where they could act as pharmacological or medicinal agents, will be investigated. Appropriate methodologies for their detection and identification, as well as for their transport, recognition by specific targets and toxicity evaluation will be developed. Experimental data will be rationalized by theoretical calculations, trying to set up or suggest more efficient species. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Researchers produce artificial compounds with anti-tumor activity 
Metal complexes demonstrate antitumoral and antiparasitic action  

Scientific publications (41)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, MARIANA MENDONCA; BIZETO, MARCOS AUGUSTO. Kinetic analysis of pH influence on the fluorescein release from chitosan-coated mesoporous silica nanoparticles. JOURNAL OF POROUS MATERIALS, v. 27, n. 4 APR 2020. Web of Science Citations: 0.
ARANDA, ESTHER ESCRIBANO; DA LUZ, JULIANA SILVA; OLIVEIRA, CARLA COLUMBANO; DIVINA PETERSEN, PHILIPPE A.; PETRILLI, HELENA M.; DA COSTA FERREIRA, ANA M. Heterobinuclear copper(II)-platinum(II) complexes with oxindolimine ligands: Interactions with DNA, and inhibition of kinase and alkaline phosphatase proteins. Journal of Inorganic Biochemistry, v. 203, FEB 2020. Web of Science Citations: 0.
FAZZI, RODRIGO B.; FERRAZ DE PAIVA, RAPHAEL E.; DA COSTA FERREIRA, ANA M. A combined EPR spectroscopy and DFT-based structural interpretation of the antitumor properties of oxindolimine-copper(II) complexes. ARKIVOC, n. 2, p. 123-133, 2020. Web of Science Citations: 0.
MACEDO, RAFAEL DOS SANTOS; ULSEN, CARINA; MUELLER, ANETTE. Quantification of residual cement paste on recycled concrete aggregates containing limestone by selective dissolution. CONSTRUCTION AND BUILDING MATERIALS, v. 229, DEC 30 2019. Web of Science Citations: 0.
DARIO, BRUNO SOARES; NETO, FRANCISCO FERNANDES; PORTES, MARCELO CECCONI; FAZZI, RODRIGO BONI; DA SILVA, DANIEL RODRIGUES; PETERSON, ERICA J.; FARRELL, NICHOLAS PATRICK; CASTELLI, SILVIA; DESIDERI, ALESSANDRO; DIVINA PETERSEN, PHILIPPE ALEXANDRE; PETRILLI, HELENA MARIA; DA COSTA FERREIRA, ANA MARIA. DNA binding, cytotoxic effects and probable targets of an oxindolimine-vanadyl complex as an antitumor agent. NEW JOURNAL OF CHEMISTRY, v. 43, n. 45, p. 17831-17840, DEC 7 2019. Web of Science Citations: 0.
RIBEIRO DE CASTRO LIMA, CIBELE ROSANA; ALVES DE COUTO, RICARDO ALEXANDRE; FREIRE, THAMIRES BATELLO; GOSHIYAMA, ALESSANDRA MARI; BABY, ANDRE ROLIM; ROBLES VELASCO, MARIA VALERIA; LEOPOLDO CONSTANTINO, VERA REGINA; MATOS, JIVALDO DO ROSARIO. Heat-damaged evaluation of virgin hair. Journal of Cosmetic Dermatology, v. 18, n. 6, p. 1885-1892, DEC 2019. Web of Science Citations: 0.
NUNES, CLEIA JUSTINO; OTAKE, ANDREIA HANADA; BUSTOS, SILVINA ODETE; FAZZI, RODRIGO BONI; CHAMMAS, ROGER; DA COSTA FERREIRA, ANA MARIA. Unlike reactivity of mono- and binuclear imine-copper(II) complexes toward melanoma cells via a tyrosinase-dependent mechanism. Chemico-Biological Interactions, v. 311, SEP 25 2019. Web of Science Citations: 1.
DE MATOS, CAROLINE S.; NOBREGA, MARCELO M.; TEMPERINI, MARCIA L. A.; CONSTANTINO, VERA R. L. Hybrid Ni-Al layered double hydroxide: Characterization and in situ synchrotron XRD and vibrational spectroscopic studies under high-pressure. APPLIED CLAY SCIENCE, v. 174, p. 152-158, JUN 15 2019. Web of Science Citations: 0.
FELTRAN, GEORGIA DA SILVA; DA COSTA FERNANDES, CELIO JUNIOR; FERREIRA, MARCEL RODRIGUES; KANG, HA RAM; DE CARVALHO BOVOLATO, ANA LIVIA; GOLIM, MARJORIE DE ASSIS; DEFFUNE, ELENICE; JUN KOH, IVAN HONG; LEOPOLDO CONSTANTINO, VERA REGINA; ZAMBUZZI, WILLIAN F. Sonic hedgehog drives layered double hydroxides-induced acute inflammatory landscape. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 174, p. 467-475, FEB 1 2019. Web of Science Citations: 2.
CAVICCHIOL, MAURICIO; LINO ZABALLA, ALINE MONTEIRO; DE PAULA, QUEITE ANTONIA; PRIETO, MARCELA BACH; OLIVEIRA, CARLA COLUMBANO; CIVITAREALE, PATRIZIA; CIRIOLO, MARIA ROSA; DA COSTA FERREIRA, ANA MARIA. Oxidative Assets Toward Biomolecules and Cytotoxicity of New Oxindolimine-Copper(II) and Zinc(II) Complexes. INORGANICS, v. 7, n. 2 FEB 2019. Web of Science Citations: 1.
VIEIRA, EDUARDO GUIMARAES; MIGUEL, RODRIGO BERNARDI; DA SILVA, DANIEL RODRIGUES; FAZZI, RODRIGO BONI; ALVES DE COUTO, RICARDO ALEXANDRE; MARIN, JAYR HENRIQUE; ARRUDA TEMPERINI, MARCIA LAUDELINA; SHINOHARA, JORGE DA SILVA; TOMA, HENRIQUE EISI; RUSSO, LILIAN CRISTINA; MAGALHAES, YULI THAMIRES; DIAS FILHO, NEWTON LUIZ; FORTI, FABIO LUIZ; DA COSTA FERREIRA, ANA MARIA. Functionalized nanoparticles as adjuvant to increase the cytotoxicity of metallodrugs toward tumor cells. NEW JOURNAL OF CHEMISTRY, v. 43, n. 1, p. 386-398, JAN 7 2019. Web of Science Citations: 2.
COSTA, MARCELA BLOISE; BIZETO, MARCOS AUGUSTO. Synthesis of a highly hydrophobic silica mesostructure by a modified co-condensation procedure and evaluation of its drug release capability. JOURNAL OF POROUS MATERIALS, v. 25, n. 6, p. 1603-1609, DEC 2018. Web of Science Citations: 3.
FIGUEIRECLO, MARIANA P.; CUNH, VANESSA R. R.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; NAKAMAE, MARTA N.; KANG, YE R.; SOUZA, RODRIGO B.; MARTINS, ANA MARIA C. R. P. F.; JUN KOH, IVAN HONG; CONSTANTINO, VERA R. L. Iron-Based Layered Double Hydroxide Implants: Potential Drug Delivery Carriers with Tissue Biointegration Promotion and Blood Microcirculation Preservation. ACS OMEGA, v. 3, n. 12, p. 18263-18274, DEC 2018. Web of Science Citations: 0.
SILVA, CLAUDIO H. B.; ILIUT, MARIA; MURYN, CHRISTOPHER; BERGER, CHRISTIAN; COLDRICK, ZACHARY; CONSTANTINO, VERA R. L.; TEMPERINI, MARCIA L. A.; VIJAYARAGHAVAN, ARAVIND. Ternary nanocomposites of reduced graphene oxide, polyaniline and hexaniobate: hierarchical architecture and high polaron formation. BEILSTEIN JOURNAL OF NANOTECHNOLOGY, v. 9, p. 2936-2945, NOV 26 2018. Web of Science Citations: 3.
CASTELLI, SILVIA; GONCALVES, MARCOS BROWN; KATKAR, PRAFULLA; STUCHI, GABRIELA CRISTINA; ALVES COUTO, RICARDO ALEXANDRE; PETRILLI, HELENA MARIA; DA COSTA FERREIRA, ANA MARIA. Comparative studies of oxindolimine-metal complexes as inhibitors of human DNA topoisomerase IB. Journal of Inorganic Biochemistry, v. 186, p. 85-94, SEP 2018. Web of Science Citations: 3.
VIEIRA, ADRIANA PIRES; WEGERMANN, CAMILA ANCHAU; DA COSTA FERREIRA, ANA MARIA. Comparative studies of Schiff base-copper(II) and zinc(II) complexes regarding their DNA binding ability and cytotoxicity against sarcoma cells. NEW JOURNAL OF CHEMISTRY, v. 42, n. 15, p. 13169-13179, AUG 7 2018. Web of Science Citations: 5.
BEMARDINO, N. D.; CONSTANTINO, V. R. L.; DE FARIA, D. L. A. Probing the Indigo Molecule in Maya Blue Simulants with Resonance Raman Spectroscopy. Journal of Physical Chemistry C, v. 122, n. 21, p. 11505-11515, MAY 31 2018. Web of Science Citations: 3.
KANG, HA RAM; DA COSTA FERNANDES, CELIO JUNIOR; DA SILVA, RODRIGO AUGUSTO; LEOPOLDO CONSTANTINO, VERA REGINA; JUN KOH, IVAN HONG; ZAMBUZZI, WILLIAN F. Mg-Al and Zn-Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen-Activated Protein Kinases. ADVANCED HEALTHCARE MATERIALS, v. 7, n. 4 FEB 21 2018. Web of Science Citations: 8.
BERNARDINO, NATHALIA D.; CONSTANTINO, VERA R. L.; DE FARIA, DALVA L. A. Probing the chemical reactivity of interfaces: Investigation on the interaction of dehydroindigo with Laponite by UV-vis, Raman and infrared spectroscopy. VIBRATIONAL SPECTROSCOPY, v. 94, p. 83-88, JAN 2018. Web of Science Citations: 2.
DE PAULA, QUEITE A.; JOLY, JEAN-PIERRE; SELMECZI, KATALIN; FONSECA, DAVID E. P.; CARAMORI, GIOVANNI F.; FARRELL, NICHOLAS P.; DA COSTA FERREIRA, ANA M. Binding affinity studies of 1,2,3-triazole copper(II) complexes to human serum albumin. Journal of Coordination Chemistry, v. 71, n. 11-13, SI, p. 1894-1909, 2018. Web of Science Citations: 0.
ARNDT, ANDERSON; LIRIA, CLEBER WANDERLEI; YOKOYAMA-YASUNAKA, JENICER K. U.; TERESA MACHINI, M.; BORTOLIN UHANA, SILVIA RENI; ESPOSITO, BRENO PANNIA. New iminodibenzyl derivatives with anti-leishmanial activity. Journal of Inorganic Biochemistry, v. 172, p. 9-15, JUL 2017. Web of Science Citations: 1.
PEROTTI, GUSTAVO F.; KIJCHAVENGKUL, THITISILP; AURAS, RAFAEL A.; CONSTANTINO, VERAR. L. Nanocomposites Based on Cassava Starch and Chitosan-Modified Clay: Physico-Mechanical Properties and Biodegradability in Simulated Compost Soil. Journal of the Brazilian Chemical Society, v. 28, n. 4, p. 649-658, APR 2017. Web of Science Citations: 10.
ALTA, ROXANA Y. P.; VITORINO, HECTOR A.; GOSWAMI, DIBAKAR; LIRIA, CLEBER W.; WISNOVSKY, SIMON P.; KELLEY, SHANA O.; MACHINI, M. TERESA; ESPOSITO, BRENO P. Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron. PLoS One, v. 12, n. 2 FEB 8 2017. Web of Science Citations: 8.
GUSTAVO F PEROTTI; THITISILP KIJCHAVENGKUL; RAFAEL A AURAS; VERA R. L CONSTANTINO. Nanocomposites Based on Cassava Starch and Chitosan-Modified Clay: Physico‑Mechanical Properties and Biodegradability in Simulated Compost Soil. Journal of the Brazilian Chemical Society, v. 28, n. 4, p. -, Abr. 2017.
ALVARADO HUAYHUAZ, JESUS ANTONIO; VITORINO, HECTOR AGUILAR; CAMPOS, OTHON SOUTO; PIRES SERRANO, SILVIA HELENA; KANEKO, TELMA MARY; ESPOSITO, BRENO PANNIA. Desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the Trojan Horse Effect. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 41, p. 16-22, 2017. Web of Science Citations: 2.
RODRIGUES CUNHA, VANESSA ROBERTA; DE SOUZA, RODRIGO BARBOSA; PINTO DA FONSECA MARTINS, ANA MARIA CRISTINA REBELLO; JUN KOH, IVAN HONG; LEOPOLDO CONSTANTINO, VERA REGINA. Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation. SCIENTIFIC REPORTS, v. 6, AUG 2 2016. Web of Science Citations: 20.
EUFRASIO PINTO, MARINA DE CARVALHO; LIMA GONCALVES, ROSEMBERGUE GABRIEL; MENEZES DOS SANTOS, RODRIGO MORAIS; ARAUJO, EMILIANE ANDRADE; PEROTTI, GUSTAVO FRIGI; MACEDO, RAFAEL DOS SANTOS; BIZETO, MARCOS AUGUSTO; LEOPOLDO CONSTANTINO, VERA REGINA; PINTO, FREDERICO GARCIA; TRONTO, JAIRO. Mesoporous carbon derived from a biopolymer and a clay: Preparation, characterization and application for an organochlorine pesticide adsorption. Microporous and Mesoporous Materials, v. 225, p. 342-354, MAY 1 2016. Web of Science Citations: 14.
OLIVEIRA, ROSELAINE DA S.; CAMILO, FERNANDA F.; BIZETO, MARCOS A. Evaluation of the influence of sulfur-based functional groups on the embedding of silver nanoparticles into the pores of MCM-41. Journal of Solid State Chemistry, v. 235, p. 125-131, MAR 2016. Web of Science Citations: 9.
PORTES, MARCELO CECCONI; DE MORAES, JOSUE; COSTA VERAS, LEIZ MARIA; LEITE, JOSE ROBERTO; MAFUD, ANA CAROLINA; MASCARENHAS, YVONNE PRIMERANO; VIRGINO LUZ, ADAMOR ELEIEL; DALMATTI ALVES DE LIMA, FILIPE CAMARGO; DO NASCIMENTO, RAFAEL RODRIGUES; PETRILLI, HELENA MARIA; SILVA PINTO, PEDRO LUIZ; ALTHOFF, GERHARD; DA COSTA FERREIRA, ANA MARIA. Structural and spectroscopic characterization of epiisopiloturine-metal complexes, and anthelmintic activity vs. S-mansoni. Journal of Coordination Chemistry, v. 69, n. 10, p. 1663-1683, 2016. Web of Science Citations: 2.
ROCHA, MICHELE A.; PETERSEN, PHILIPPE A. D.; TEIXEIRA-NETO, ERICO; PETRILLI, HELENA M.; LEROUX, FABRICE; TAVIOT-GUEHO, CHRISTINE; CONSTANTINO, VERA R. L. Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release. RSC ADVANCES, v. 6, n. 20, p. 16419-16436, 2016. Web of Science Citations: 20.
DE MORAES, JOSUE; DARIO, BRUNO S.; COUTO, RICARDO A. A.; PINTO, PEDRO L. S.; DA COSTA FERREIRA, ANA M. Antischistosomal Activity of Oxindolimine-Metal Complexes. Antimicrobial Agents and Chemotherapy, v. 59, n. 10, p. 6648-6652, OCT 2015. Web of Science Citations: 10.
MIGUEL, RODRIGO BERNARDI; DIVINA PETERSEN, PHILIPPE ALEXANDRE; GONZALES-ZUBIATE, FERNANDO A.; OLIVEIRA, CARLA COLUMBANO; KUMAR, NARESH; DO NASCIMENTO, RAFAEL RODRIGUES; PETRILLI, HELENA MARIA; DA COSTA FERREIRA, ANA MARIA. Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, v. 20, n. 7, p. 1205-1217, OCT 2015. Web of Science Citations: 9.
NUNES, CLEIA JUSTIN; BORGES, BEATRIZ ESSENFELDER; NAKAO, LIA SUMIE; PEYROUX, EUGENIE; HARDRE, RENAUD; FAURE, BRUNO; REGLIER, MARIUS; GIORGI, MICHEL; PRIETO, MARCELA BACH; OLIVEIRA, CARLA COLUMBANO; DA COSTA FERREIRA, ANA M. Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity. Journal of Inorganic Biochemistry, v. 149, p. 49-58, AUG 2015. Web of Science Citations: 3.
VITORINO, HECTOR AGUILAR; MANTOVANELLI, LUCA; ZANOTTO, FLAVIA PINHEIRO; ESPOSITO, BRENO PANNIA. Iron Metallodrugs: Stability, Redox Activity and Toxicity against Artemia salina. PLoS One, v. 10, n. 4 APR 7 2015. Web of Science Citations: 11.
PEROTTI, GUSTAVO F.; BARUD, HERNANE S.; RIBEIRO, SIDNEY J. L.; CONSTANTINO, VERA R. L. Bacterial Cellulose as a Template for Preparation of Hydrotalcite-Like Compounds. Journal of the Brazilian Chemical Society, v. 25, n. 9, p. 1647-1655, SEP 2014. Web of Science Citations: 7.
SCHLEH, FREDERICO A.; CHIARELLI-NETO, ORLANDO; FONTES, MAYARA N.; NAJJAR, RENATO; ESPOSITO, BRENO P. Phytate Decreases Oxidative Damage Caused by Labile Forms of Iron in Solution, Blood Plasma and in HeLa Cells. Journal of the Brazilian Chemical Society, v. 25, n. 6, p. 1036-1040, JUN 2014. Web of Science Citations: 1.
CUNHA, VANESSA R. R.; IZUMI, CELLY M. S.; PETERSEN, PHILIPPE A. D.; MAGALHAES, ALVICLER; TEMPERINI, MARCIA L. A.; PETRILLI, HELENA M.; CONSTANTINO, VERA R. L. Mefenamic Acid Anti-Inflammatory Drug: Probing Its Polymorphs by Vibrational (IR and Raman) and Solid-State NMR Spectroscopies. Journal of Physical Chemistry B, v. 118, n. 16, p. 4333-4344, APR 24 2014. Web of Science Citations: 17.
KATKAR, PRAFULLA; COLETTA, ANDREA; CASTELLI, SILVIA; SABINO, GUSTAVO L.; ALVES COUTO, RICARDO A.; DA COSTA FERREIRA, ANA M.; DESIDERI, ALESSANDRO. Effect of oxindolimine copper(II) and zinc(II) complexes on human topoisomerase I activity. METALLOMICS, v. 6, n. 1, p. 117-125, 2014. Web of Science Citations: 23.
PEROTTI, GUSTAVO F.; TRONTO, JAIRO; BIZETO, MARCOS A.; IZUMI, CELLY M. S.; TEMPERINI, MARCIA L. A.; LUGAO, ADEMAR B.; PARRA, DUCLERC F.; CONSTANTINO, VERA R. L. Biopolymer-Clay Nanocomposites: Cassava Starch and Synthetic Clay Cast Films. Journal of the Brazilian Chemical Society, v. 25, n. 2, p. 320-330, Fev. 2014. Web of Science Citations: 16.
PEREIRA, TATIANA ARAUJO; TEIXEIRA DA SILVA, GISELE ESPINHA; HERNANDEZ, RAUL BONNE; FORTI, FABIO LUIS; ESPOSITO, BRENO PANNIA. Antitumor activity of Mn(III) complexes in combination with phototherapy and antioxidant therapy. BIOMETALS, v. 26, n. 3, p. 439-446, JUN 2013. Web of Science Citations: 4.
SILVEIRA, VIVIAN C.; ABBOTT, MARIANA P.; CAVICCHIOLI, MAURICIO; GONCALVES, MARCOS B.; PETRILLI, HELENA M.; DE REZENDE, LEANDRO; AMARAL, ANTONIA T.; FONSECA, DAVID E. P.; CARAMORI, GIOVANNI F.; DA COSTA FERREIRA, ANA M. Peculiar reactivity of a di-imine copper(II) complex regarding its binding to albumin protein. DALTON TRANSACTIONS, v. 42, n. 18, p. 6386-6396, 2013. Web of Science Citations: 13.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

COMPLEXOS METÁLICOS COM LIGANTES INDÓLICOS OU OXINDÓLICOS E SEUS DERIVADOS IMiNICOS E SEU USO COMO AGENTES ANTIPARASITÁRIOS BR1020130265586 - Universidade de São Paulo (USP) ; Universidade Federal de Minas Gerais (UFMG) . Ana Maria da C. Ferreira; Gustavo Levendoski Sabino; Queite Antonia de Paula; Ricardo Alexandre de Couto; Bruno Soares Dario; Leda Quercia Vieira; Grazielle Alves Ribeiro - October 2013, 15