Abstract
In this project, we intend to improve and expand studies under development in our laboratory, initiated 4 years ago (Process FAPESP No 01/09127-6). Investigations on the structure and reactivity of metal complexes, involving essential metal ions such as iron, copper, zinc, manganese, vanadium or cobalt, as well as heavy metal ions such as ruthenium, free in solution and also inserted in different matrices, have been carried out by 3 research groups, in the area of Inorganic Chemistry, with complementary interests. The main goals for this new period are: 1) design and development of adequate methodologies for the preparation of several coordination compounds with essential and non-essential metal ions, and different ligands, with the aim of obtaining potential metallopharmaceuticals or new catalysts; 2) preparation and utilization of coordination compounds of iron and copper, in solution or inserted in inorganic frameworks, as catalysts for oxidation of pollutants, contaminants and industrial effluents by advanced oxidation processes; 3) preparation of lamellar host structures and their "nanoscroll" derivatives, with the aim of obtaining better catalysts for environmental purposes, or hybrid organic-inorganic materials with peculiar properties; 4) immobilization and/or encapsulating of pharmaceuticals and metallopharmaceuticals, in double lamellar hydroxides, and in natural organic polymers, with the aim of improving their pharmacological activity, decreasing collateral effects, and allowing a controlled release in the organism; 5) physicochemical characterization of the new prepared species, by using more conventional techniques as well as modern ones, specially ESI-MS, XANES, EXAFS and TGA-DSC-MS; 6) evaluation of possible biological activities of the free metallo- and/or immobilized-species prepared, in different processes of biological importance. (AU)
Scientific publications
(16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, DOUGLAS DE J.;
HANIF-UR-REHMAN;
ALVES RICO, SAMARA R.;
COSTA, IGUATINA DE M.;
PIO SANTOS, ANDREA C.;
SZSZUDLOWSKI, RACHEL G.;
SILVA, DENISE DE OLIVEIRA.
Interaction of chitosan beads with a copper-naproxen metallodrug.
RSC ADVANCES,
v. 5,
n. 109,
p. 90184-90192,
2015.
Web of Science Citations: 3.
MIYAKE, JULIANO ANDREOLI;
BENADIBA, MARCEL;
RIBEIRO, GEISE;
SILVA, DENISE DE OLIVEIRA;
COLQUHOUN, ALISON.
Novel Ruthenium - Gamma-linolenic Acid Complex Inhibits C6 Rat Glioma Cell Proliferation In Vitro and in the Orthotopic C6 Model In Vivo After Osmotic Pump Infusion.
ANTICANCER RESEARCH,
v. 34,
n. 4, SI,
p. 1901-1911,
APR 2014.
Web of Science Citations: 15.
KABEYA, LUCIANA M.;
FUZISSAKI, CAROLINA N.;
TALEB-CONTINI, SILVIA H.;
FERREIRA, ANA MARIA DA C.;
NAAL, ZEKI;
SANTOS, EVERTON O. L.;
FIGUEIREDO-RINHEL, ANDREA S. G.;
AZZOLINI, ANA ELISA C. S.;
VERMELHO, ROBERTA B.;
MALVEZZI, ALBERTO;
DO AMARAL, ANTONIA T.;
LOPES, JOAO LUIS C.;
LUCISANO-VALIM, YARA MARIA.
7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils.
Chemico-Biological Interactions,
v. 206,
n. 1,
p. 63-75,
OCT 25 2013.
Web of Science Citations: 7.
LIBERATO, MICHELLE S.;
KOGIKOSKI, JR., SERGIO;
SILVA, EMERSON R.;
COUTINHO-NETO, MAURICIO D.;
SCOTT, LUIS P. B.;
SILVA, RICARDO H.;
OLIVEIRA, JR., VANI X.;
ANDO, ROMULO A.;
ALVES, WENDEL A.
Self-Assembly of Arg-Phe Nanostructures via the Solid-Vapor Phase Method.
Journal of Physical Chemistry B,
v. 117,
n. 3,
p. 733-740,
JAN 24 2013.
Web of Science Citations: 14.
SILVEIRA, VIVIAN C.;
ABBOTT, MARIANA P.;
CAVICCHIOLI, MAURICIO;
GONCALVES, MARCOS B.;
PETRILLI, HELENA M.;
DE REZENDE, LEANDRO;
AMARAL, ANTONIA T.;
FONSECA, DAVID E. P.;
CARAMORI, GIOVANNI F.;
DA COSTA FERREIRA, ANA M.
Peculiar reactivity of a di-imine copper(II) complex regarding its binding to albumin protein.
DALTON TRANSACTIONS,
v. 42,
n. 18,
p. 6386-6396,
2013.
Web of Science Citations: 13.
DA SILVEIRA, VIVIAN CHAGAS;
BENEZRA, HENRI;
LUZ, JULIANA SILVA;
GEORG, RAPHAELA CASTRO;
OLIVEIRA, CARLA COLUMBANO;
DA COSTA FERREIRA, ANA MARIA.
Binding of oxindole-Schiff base copper(II) complexes to DNA and its modulation by the ligand.
Journal of Inorganic Biochemistry,
v. 105,
n. 12, SI,
p. 1692-1703,
DEC 2011.
Web of Science Citations: 35.
ALVES, WENDEL A.;
SANT'ANA, ANTONIO C.;
ABBOTT, MARIANA P.;
HOMEM-DE-MELLO, PAULA;
MARTINHO, HERCULANO;
SANTOS, REGINA H. A.;
FERREIRA, JANAINA G.;
TEMPERINI, MARCIA L. A.;
PADUAN-FILHO, ARMANDO;
DA COSTA FERREIRA, ANA MARIA.
Dinuclear Azide-Bridged Copper(II) Complex as Building Block for the Assembly of a 2D-Supramolecular Array.
Science of Advanced Materials,
v. 2,
n. 2, SI,
p. 173-183,
JUN 2010.
Web of Science Citations: 2.
AZZELLINI, M. AMELIA A.;
ABBOTT, MARIANA P.;
MACHADO, ALESSANDRA;
MIRANDA, M. TERESA M.;
GARCIA, LEONE C.;
CARAMORI, GIOVANNI F.;
GONCALVES, MARCOS B.;
PETRILLI, HELENA M.;
FERREIRA, ANA M. C.
Interactions of di-Imine Copper(II) Complexes with Albumin: Competitive Equilibria, Promoted Oxidative Damage and DFT Studies.
Journal of the Brazilian Chemical Society,
v. 21,
n. 7,
p. 1303-1317,
2010.
Web of Science Citations: 13.
DIAS, PATRICIA M.;
KINOUTI, LILIAN;
CONSTANTINO, VERA R. L.;
FERREIRA, ANA M. D. C.;
GONCALVES, MARCOS B.;
DO NASCIMENTO, RAFAEL R.;
PETRILLI, HELENA M.;
CALDAS, MARILIA;
FREM, REGINA C. G.
SPECTROSCOPIC CHARACTERIZATION OF SCHIFF BASE-COPPER COMPLEXES IMMOBILIZED IN SMECTITE CLAYS.
Química Nova,
v. 33,
n. 10,
p. 2135-2142,
2010.
Web of Science Citations: 2.
ALVES, WENDEL A.;
MATOS, IORQUIRENE O.;
TAKAHASHI, PEDRO M.;
BASTOS, ERICK L.;
MARTINHO, HERCULANO;
FERREIRA, JANAINA G.;
SILVA, CLAUDIA C.;
DE ALMEIDA SANTOS, REGINA H.;
PADUAN-FILHO, ARMANDO;
DA COSTA FERREIRA, ANA M.
A Chloro-Bridged Linear Chain Imine-Copper(II) Complex and Its Application as an Enzyme-Free Amperometric Biosensor for Hydrogen Peroxide.
European Journal of Inorganic Chemistry,
n. 15,
p. 2219-2228,
MAY 2009.
Web of Science Citations: 17.