Synthesis and characterization of hybrid materials based on layered double hydroxides and bioactive organic species.

• Grant number: 12/06291-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2012
• End date: February 28, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Vera Regina Leopoldo Constantino
• Grantee: Caroline Silva de Matos
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media, AP.TEM

Abstract

Intercalation Chemistry is an area in which the development of materials of pharmacological interest has been increasingly exploited. In this context, layered double hydroxides (LDH) emerge as potential carriers in which anionic species of biological concern can be confined. LDH have several characteristics required for a good therapeutical vehicle, emphasizing the biocompatibility and biodegradability. In addition to these important requirements, LDH can promote the controlled release of the confined species, given their susceptibility to changes in pH and the large range of ions that can be inserted between the layers. This research project aims to study the synthesis parameters and the chemical, structural and spectroscopic characterization of LDH with composition M2+/Al3+ (where M = Mg or Zn) and molar ratio equal to 3, intercalated with anions derived from folic, carminic and rosmarinic acids (whose properties allow interesting pharmacological applications). The synthesis will be carried out using the method of co-precipitation in constant pH, starting from chlorides of the metal ions and an aqueous solution of the anion to be intercalated, verifying the influence of pH, reaction time and the molar ratio anion/Al3+ on the obtained materials. After synthesis, the materials may undergo heat treatment and then be isolated. The materials obtained will be characterized by X-ray diffraction, elemental and thermal analysis, vibrational spectroscopy and measurements of particle size and Zeta potential.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MAGRI, VAGNER R.; DE MATOS, CAROLINE S.; ROCHA, MICHELE A.; TAVIOT-GUEHO, CHRISTINE; CONSTANTINO, VERA R. L.. Revisiting the Synthesis and Characterization of Hybrid Nanomaterial Constituted by Folate Intercalated into M2+/Al3+(M2+=Mg2+and Zn2+) Layered Double Hydroxide. Journal of the Brazilian Chemical Society, v. 35, n. 12, p. 12-pg., 2024-01-01. (14/50869-6, 12/06291-4)

MAGRI, VAGNER R.; DE MATOS, CAROLINE S.; ROCHA, MICHELE A.; TAVIOT-GUEHO, CHRISTINE; CONSTANTINO, VERA R. L.. Pyrolysis of folic acid: Identification of gaseous/volatile products and structural evolution of N-doped graphitic carbon. Thermochimica Acta, v. 739, p. 11-pg., 2024-07-19. (14/50869-6, 12/06291-4)

MAGRI, VAGNER R. R.; ROCHA, MICHELE A.; LEROUX, FABRICE; PETRILLI, HELENA M. M.; DE MATOS, CAROLINE S.; PETERSEN, PHILIPPE A. D.; CONSTANTINO, VERA R. L.. Folic acid and sodium folate salts: Thermal behavior and spectroscopic (IR, Raman, and solid-state C-13 NMR) characterization. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 273, p. 13-pg., 2022-02-23. (16/50317-9, 12/06291-4)