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Inorganic carriers of bioactive substances: development, characterization, toxicity evaluation of in vitro delivery and in vivo absorption after oral administration

Grant number: 12/12209-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2013
Effective date (End): August 22, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Vera Regina Leopoldo Constantino
Grantee:Vanessa Roberta Rodrigues da Cunha
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media, AP.TEM


The health field interest in studies related to the use of carriers for the confinement of biological active molecules such as drugs has increased exponentially in recent years. Among the reasons for such studies is the increase in solubility, photochemical and thermal stability, sustained delivery and/or specific target and the possible decrease of side effects of these bioactive molecules. In this context, it is observed the importance assigned to Layered Double Hydroxides (LDHs) for these purposes due to some important properties of these inorganic nanoparticles, such as low toxicity, high biocompatibility and antacid character. The elucidation of the behavior of these host matrices in the biological environment through in vitro and in vivo assays is extremely important but still emerging. This project aims to investigate the behavior of the LDHs in biological environment by in vitro and in vivo tests to follow the process of interaction with the intestinal epithelium and subsequent incorporation through the lymphatic and hematological pathways up to the systemic circulation and the successive via of the carriers excretion in rats. Therefore, the LDHs (containing species with the followed biological activities: dyslipidemia, anti-inflammatory and/or antioxidant) will be previously characterized using a wide set of physicochemical techniques: XRD; Thermal Analysis; Chemical Elemental Analysis; Eletronic Microscopy; Particle Size and Zeta Potential; IR, Raman and 13C NMR Spectroscopies (the experimental spectroscopic data will be supported by computational calculation using the DFT method). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CUNHA, VANESSA R. R.; LIMA, FILIPE C. D. A.; SAKAI, VANESSA Y.; VERAS, LEIZ M. C.; LEITE, JOSE R. S. A.; PETRILLI, HELENA M.; CONSTANTINO, VERA R. L. LAPONITE (R)-pilocarpine hybrid material: experimental and theoretical evaluation of pilocarpine conformation. RSC ADVANCES, v. 7, n. 44, p. 27290-27298, 2017. Web of Science Citations: 4.
RODRIGUES CUNHA, VANESSA ROBERTA; DE SOUZA, RODRIGO BARBOSA; PINTO DA FONSECA MARTINS, ANA MARIA CRISTINA REBELLO; JUN KOH, IVAN HONG; LEOPOLDO CONSTANTINO, VERA REGINA. Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation. SCIENTIFIC REPORTS, v. 6, AUG 2 2016. Web of Science Citations: 20.
CUNHA, VANESSA R. R.; IZUMI, CELLY M. S.; PETERSEN, PHILIPPE A. D.; MAGALHAES, ALVICLER; TEMPERINI, MARCIA L. A.; PETRILLI, HELENA M.; CONSTANTINO, VERA R. L. Mefenamic Acid Anti-Inflammatory Drug: Probing Its Polymorphs by Vibrational (IR and Raman) and Solid-State NMR Spectroscopies. Journal of Physical Chemistry B, v. 118, n. 16, p. 4333-4344, APR 24 2014. Web of Science Citations: 17.

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