MRI Texture Analysis Reveals Deep Gray Nuclei Damage in Amyotrophic Lateral Sclerosis

Autor(es)

de Albuquerque, Milena ^{[1, 2]} ; Anjos, Lara G. V. ^{[1, 2]} ; Tavares de Andrade, Helen Maia ^{[1, 2]} ; de Oliveira, Marcia S. ^[3] ; Castellano, Gabriela ^[3] ; Ribeiro de Rezende, Thiago Junqueira ^{[3, 1, 2]} ; Nucci, Anamarli ^{[1, 2]} ; Franca Junior, Marcondes Cavalcante ^{[1, 2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Med Sci, Dept Neurol, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Med Sci, Dept Neuroimaging Lab, Campinas, SP - Brazil

^[3] Univ Campinas UNICAMP, Inst Phys Gleb Wataghin, Neurophys Grp, Campinas, SP - Brazil

^[4] Univ Campinas UNICAMP, Dept Neurol, Rua Tessalia Vieira de Camargo, 126 Cidade Univ Ze, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF NEUROIMAGING; v. 26, n. 2, p. 201-206, MAR-APR 2016.
• Citações Web of Science: 14

Resumo

BACKGROUND AND PURPOSEAmyotrophic Lateral Sclerosis (ALS) is characterized by extensive corticospinal damage, but extrapyramidal involvement is suggested in pathological studies. Texture analysis (TA) is an image processing technique that evaluates the distribution of gray levels between pixels in a given region of interest (ROI). It provides quantitative data and has been employed in several neurodegenerative disorders. Here, we used TA to investigate possible deep gray nuclei (DGN) abnormalities in a cohort of ALS patients. METHODSThirty-two ALS patients and 32 healthy controls underwent MRI in a 3T scanner. The T1 volumetric sequence was used for DGN segmentation and extraction of 11 texture parameters using the MaZda software. Statistical analyses were performed using the Mann-Whitney non-parametric test, with a significance level set at = 0.025 (FDR-corrected) for TA. RESULTSPatients had significantly higher values for the parameter correlation (CO) in both thalami and in the right caudate nucleus compared to healthy controls. Also, the parameter Inverse Difference Moment or Homogeneity (IDM) presented significantly smaller values in the ALS group in both thalami. CONCLUSIONSTA of T1 weighted images revealed DGN alterations in patients with ALS, namely in the thalami and caudate nuclei. (AU)

• Processo FAPESP: 12/24363-2 - Uso do modelo de causalidade de Granger para o estudo da conectividade efetiva de imagens de ressonância magnética funcional, adquiridas em experimentos de memória verbal, visual e operacional, em indivíduos sadios e pacientes com epilepsias refratárias
• Beneficiário: Márcia Silva de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 11/21521-3 - Estudo de biomarcadores na esclerose lateral amiotrófica
• Beneficiário: Milena de Albuquerque
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto