Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections

Autor(es)

Assone, Tatiane ^{[1, 2]} ; Paiva, Arthur ^[2] ; Fonseca, Luiz Augusto M. ^[3] ; Casseb, Jorge ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immune Deficiencies, LIM56, Av Dr Eneas de Carvalho Aguiar 500, 3rd Floo, Sao Paulo, SP - Brazil

^[2] Inst Trop Med Sao Paulo, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Viruses-Basel; v. 8, n. 2 FEB 2016.
• Citações Web of Science: 7

Resumo

Human T-cell leukemia virus type 1 (HTLV-1), hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) are prevalent worldwide, and share similar means of transmission. These infections may influence each other in evolution and outcome, including cancer or immunodeficiency. Many studies have reported the influence of genetic markers on the host immune response against different persistent viral infections, such as HTLV-1 infection, pointing to the importance of the individual genetic background on their outcomes. However, despite recent advances on the knowledge of the pathogenesis of HTLV-1 infection, gaps in the understanding of the role of the individual genetic background on the progress to disease clinically manifested still remain. In this scenario, much less is known regarding the influence of genetic factors in the context of dual or triple infections or their influence on the underlying mechanisms that lead to outcomes that differ from those observed in monoinfection. This review describes the main factors involved in the virus-host balance, especially for some particular human leukocyte antigen (HLA) haplotypes, and other important genetic markers in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other persistent viruses, such as HIV and HCV. (AU)

• Processo FAPESP: 12/23397-0 - Determinação do perfil do polimorfismo da IL28B em indivíduos co-infectados pelo Vírus da Hepatite C crônica (HCV) e pelo vírus linfotrópico de células T humanas tipo 1 (HTLV-1)
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/22827-7 - Prevalência e incidência de alteração precoce no sistema nervoso central em pessoas infectados pelo HTLV-1
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Regular