| Texto completo | |
| Autor(es): |
Kuebler, Peter J.
[1]
;
Mehrotra, Megha L.
[2]
;
Shaw, Brian I.
[1]
;
Leadabrand, Kaitlyn S.
[1]
;
Milush, Jeffrey M.
[1]
;
York, Vanessa A.
[1]
;
Defechereux, Patricia
[2]
;
Grant, Robert M.
[3, 2]
;
Kallas, Esper G.
[4]
;
Nixon, Douglas F.
[5]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 - USA
[2] Gladstone Inst, Gladstone Inst Virol & Immunol, San Francisco, CA - USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 - USA
[4] Univ Sao Paulo, Div Clin Immunol & Allergy, BR-05508 Sao Paulo - Brazil
[5] George Washington Univ, Dept microbiol Immunol & Trop Med, Washington, DC - USA
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Infectious Diseases; v. 213, n. 4, p. 569-573, FEB 15 2016. |
| Citações Web of Science: | 5 |
| Resumo | |
We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+)CD8(+)T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+)T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk. (AU) | |
| Processo FAPESP: | 04/15856-9 - Análise prospectiva das características virológicas e imunológicas em indivíduos com infecção recente pelo HIV-1 das cidades de São Paulo e Santos, SP |
| Beneficiário: | Ricardo Sobhie Diaz |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 10/05845-0 - Resposta imune celular em doenças infecciosas e imunodeficiências primárias |
| Beneficiário: | Esper Georges Kallás |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisador Visitante - Internacional |