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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8(+) T-Cell Activation

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Kuebler, Peter J. [1] ; Mehrotra, Megha L. [2] ; Shaw, Brian I. [1] ; Leadabrand, Kaitlyn S. [1] ; Milush, Jeffrey M. [1] ; York, Vanessa A. [1] ; Defechereux, Patricia [2] ; Grant, Robert M. [3, 2] ; Kallas, Esper G. [4] ; Nixon, Douglas F. [5]
Total Authors: 10
[1] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 - USA
[2] Gladstone Inst, Gladstone Inst Virol & Immunol, San Francisco, CA - USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 - USA
[4] Univ Sao Paulo, Div Clin Immunol & Allergy, BR-05508 Sao Paulo - Brazil
[5] George Washington Univ, Dept microbiol Immunol & Trop Med, Washington, DC - USA
Total Affiliations: 5
Document type: Journal article
Source: Journal of Infectious Diseases; v. 213, n. 4, p. 569-573, FEB 15 2016.
Web of Science Citations: 5

We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+)CD8(+)T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+)T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk. (AU)

FAPESP's process: 10/05845-0 - Cellular immune responses in infectious diseases and primary immunodeficiencies
Grantee:Esper Georges Kallás
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos
Grantee:Ricardo Sobhie Diaz
Support type: Research Projects - Thematic Grants