Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos

• Grant number: 04/15856-9
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2006
• End date: March 31, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ricardo Sobhie Diaz
• Grantee: Ricardo Sobhie Diaz
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: Esper Georges Kallás ; Ester Cerdeira Sabino ; Luiz Mário Ramos Janini
• Associated research grant(s): 06/54673-2 - Scarcity of positive selected codons on the human immunodeficiency virus type 1(hiv-1) during pediatric infection., AR.EXT
• Associated scholarship(s): 07/04918-1 - Prevalence of HIV-1 tropic variants in a cohort of HIV-1 recently infected individuals from the state of São Paulo., BP.IC; 06/50096-0 - Characterization of Human Immunodeficiency Virus type 1 (HIV-1) in a cohort of recently infected persons from the State of São Paulo by full genome sequencing, BP.PD

Abstract

The objective includes the development of a cohort of individuals with recent infection from HIV-1, based on which we will conduct virological, immunological, clinical and epidemiological studies. The cohort will serve as a base for three scientific studies motivated on the basis of well defined scientific hypotheses. The study involving people with recent HIV infection will offer a unique and important analysis of the tendencies in the epidemic, of the natural history of the infection from HIV under special circumstances (universal anti-retroviral treatment) and will prospectively explore important questions which can arise in locations where the therapeutic interventions have increased. We will conduct clinical/laboratorial studies related to (i) acquisition of primary resistance to the anti-retrovirals and progression of the disease; (ii) immunological response during the recent infection from HIV and (iii) the genetic diversity of the viral population as factor related to the progression of the disease. The epidemiological analysis will include behavioral studies and correlations with co-infections. (AU)

Scientific publications

(48)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAROSSO, LEANDRO F.; VIEIRA, VINICIUS A.; SAUER, MARIANA M.; TOMIYAMA, HELENA I.; KALIL, JORGE; KALLAS, ESPER G.. Conserved HIV-1 Gag p24 Epitopes Elicit Cellular Immune Responses That Impact Disease Outcome. AIDS Research and Human Retroviruses, v. 33, n. 8, SI, p. 832-842, AUG 2017. (04/15856-9)

BERMUDEZ-AZA, ELKIN HERNAN; FRANCO SANSIGOLO KERR, LIGIA REGINA; KENDALL, CARL; PINHO, ADRIANA ARAUJO; DE MELLO, MAEVE BRITO; MOTA, ROSA SALANI; CROSLAND GUIMARAES, MARK DREW; ALENCAR, CECILIA SALETE; DE BRITO, ANA MARIA; DOURADO, INES COSTA; et al. Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v. 57, n. 3, p. S186-S192, AUG 15 2011. (04/15856-9)

ZANONI, MICHELLE; AVENTURATO, ITALO KARMANN; HUNTER, JAMES; ARARIPE SUCUPIRA, MARIA CECILIA; DIAZ, RICARDO SOBHIE. Uniquely altered transcripts are associated with immune preservation in HIV infection. PLoS One, v. 12, n. 3, MAR 28 2017. (04/15856-9)

KUEBLER, PETER J.; SHAW, BRIAN I.; LEADABRAND, KAITLYN S.; MEHROTRA, MEGHA L.; GRANT, ROBERT M.; KALLAS, ESPER G.; NIXON, DOUGLAS F.. HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v. 72, n. 2, p. 184-188, JUN 1 2016. (04/15856-9, 10/05845-0)

JAIN, VIVEK; SUCUPIRA, MARIA C.; BACCHETTI, PETER; HARTOGENSIS, WENDY; DIAZ, RICARDO S.; KALLAS, ESPER G.; JANINI, LUIZ M.; LIEGLER, TERI; PILCHER, CHRISTOPHER D.; GRANT, ROBERT M.; et al. Differential Persistence of Transmitted HIV-1 Drug Resistance Mutation Classes. Journal of Infectious Diseases, v. 203, n. 8, p. 1174-1181, APR 15 2011. (04/15856-9)

GIRET, MARIA TERESA M.; MIRAGLIA, JOAO LUIZ; ARARIPE SUCUPIRA, MARIA CECILIA; NISHIYA, ANNA; LEVI, JOSE EDUARDO; DIAZ, RICARDO S.; SABINO, ESTER C.; KALLAS, ESPER G.. Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil. PLoS One, v. 6, n. 4, APR 5 2011. (04/15856-9, 05/01072-9)

NDHLOVU, L. C.; SNYDER-CAPPIONE, J. E.; CARVALHO, K. I.; LEAL, F. E.; LOO, C. P.; BRUNO, F. R.; JHA, A. R.; DEVITA, D.; HASENKRUG, A. M.; BARBOSA, H. M. R.; et al. Lower numbers of circulating natural killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v. 158, n. 3, p. 294-299, DEC 2009. (04/15856-9)

MAIDANA-GIRET, MARIA TERESA; SILVA, TANIA M.; SAUER, MARIANA M.; TOMIYAMA, HELENA; LEVI, JOSE EDUARDO; BASSICHETTO, KATIA C.; NISHIYA, ANNA; DIAZ, RICARDO S.; SABINO, ESTER C.; PALACIOS, RICARDO; et al. GB virus type C infection modulates T-cell activation independently of HIV-1 viral load. AIDS, v. 23, n. 17, p. 2277-2287, NOV 13 2009. (04/15856-9, 05/01072-9)

SNYDER-CAPPIONE, JENNIFER E.; LOO, CHRISTOPHER P.; CARVALHO, KARINA I.; KUYLENSTIERNA, CARLOTTA; DEEKS, STEVEN G.; HECHT, FREDERICK M.; ROSENBERG, MICHAEL G.; SANDBERG, JOHAN K.; KALLAS, ESPER G.; NIXON, DOUGLAS F.. Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression. AIDS, v. 23, n. 15, p. 1965-1970, SEP 24 2009. (04/15856-9)

TAROSSO, LEANDRO F.; SANABANI, SABRI S.; RIBEIRO, SUSAN P.; SAUER, MARIANA M.; TOMIYAMA, HELENA I.; SUCUPIRA, MARIA C.; DIAZ, RICARDO S.; SABINO, ESTER C.; KALIL, JORGE; KALLAS, ESPER G.. Short Communication: HIV Type 1 Subtype BF Leads to Faster CD4(+) T Cell Loss Compared to Subtype B. AIDS Research and Human Retroviruses, v. 30, n. 2, p. 190-194, FEB 1 2014. (04/15856-9)

GAMA, LUCIO; SHIRK, ERIN N.; RUSSELL, JULIA N.; CARVALHO, KARINA I.; LI, MING; QUEEN, SUZANNE E.; KALIL, JORGE; ZINK, M. CHRISTINE; CLEMENTS, JANICE E.; KALLAS, ESPER G.. Expansion of a subset of CD14(high)CD16(neg)CCR2(low/neg) monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection. Journal of Leukocyte Biology, v. 91, n. 5, p. 803-816, MAY 2012. (04/15856-9)

SANABANI, SABRI SAEED; PESSOA, RODRIGO; SOARES DE OLIVEIRA, ANA CAROLINA; MARTINEZ, VANESSA POUZA; GIRET, MARIA TERESA MAIDANA; DE MENEZES SUCCI, REGINA CELIA; CARVALHO, KARINA; TOMIYAMA, CLAUDIA SATIKO; NIXON, DOUGLAS F.; SABINO, ESTER CERDEIRA; et al. Variability of HIV-1 Genomes among Children and Adolescents from Sao Paulo, Brazil. PLoS One, v. 8, n. 5, MAY 7 2013. (11/09983-1, 04/15856-9, 06/50096-0, 10/05845-0)

SUCUPIRA, MARIA CECILIA A.; MUNERATO, PATRICIA; SILVEIRA, JUSSARA; SANTOS, ANDRE F.; JANINI, LUIZ MARIO; SOARES, MARCELO A.; DIAZ, RICARDO SOBHIE. Phenotypic Susceptibility to Antiretrovirals Among Clades C, F, and B/F Recombinant Antiretroviral-Naive HIV Type 1 Strains. AIDS Research and Human Retroviruses, v. 29, n. 6, p. 880-886, JUN 2013. (04/15856-9)

ALMEIDA, RAFAEL RIBEIRO; ROSA, DANIELA SANTORO; RIBEIRO, SUSAN PEREIRA; SANTANA, VINICIUS CANATO; KALLAS, ESPER GEORGES; SIDNEY, JOHN; SETTE, ALESSANDRO; KALIL, JORGE; CUNHA-NETO, EDECIO. Broad and Cross-Clade CD4(+) T-Cell Responses Elicited by a DNA Vaccine Encoding Highly Conserved and Promiscuous HIV-1 M-Group Consensus Peptides. PLoS One, v. 7, n. 9, SEP 18 2012. (08/57881-0, 06/50096-0, 04/15856-9)

KUEBLER, PETER J.; MEHROTRA, MEGHA L.; SHAW, BRIAN I.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; DEFECHEREUX, PATRICIA; GRANT, ROBERT M.; KALLAS, ESPER G.; NIXON, DOUGLAS F.. Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8(+) T-Cell Activation. Journal of Infectious Diseases, v. 213, n. 4, p. 569-573, FEB 15 2016. (04/15856-9, 10/05845-0)

SCARPELINI, BRUNO; ZANONI, MICHELLE; ARARIPE SUCUPIRA, MARIA CECILIA; TRUONG, HONG-HA M.; RAMOS JANINI, LUIZ MARIO; COTRIN SEGURADO, ISMAEL DALE; SOBHIE DIAZ, RICARDO. Plasma Metabolomics Biosignature According to HIV Stage of Infection, Pace of Disease Progression, Viremia Level and Immunological Response to Treatment. PLoS One, v. 11, n. 12, DEC 12 2016. (04/15856-9)

TAROSSO, LEANDRO F.; VIEIRA, VINICIUS A.; SAUER, MARIANA M.; TOMIYAMA, HELENA I.; KALIL, JORGE; KALLAS, ESPER G.. Conserved HIV-1 Gag p24 Epitopes Elicit Cellular Immune Responses That Impact Disease Outcome. AIDS Research and Human Retroviruses, v. 33, n. 8, p. 11-pg., 2017-08-01. (04/15856-9)

CECÍLIA SALETE ALENCAR; ESTER CERDEIRA SABINO; RICARDO SOBHIE DIAZ; ALFREDO MENDRONE-JUNIOR; ANNA SHOKO NISHIYA. Genetic diversity in the partial sequence of the HIV-1 gag gene among people living with multidrug-resistant HIV-1 infection. Revista do Instituto de Medicina Tropical de São Paulo, v. 66, 2024-06-07. (04/15856-9)

KUEBLER, PETER J.; MEHROTRA, MEGHA L.; MCCONNELL, J. JEFF; HOLDITCH, SARA J.; SHAW, BRIAN I.; TAROSSO, LEANDRO F.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; RAPOSO, RUI ANDRE SARAIVA; et al. Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 27, p. 8379-8384, JUL 7 2015. (04/15856-9, 10/05845-0)

VINICIUS CANATO SANTANA; RAFAEL RIBEIRO ALMEIDA; SUSAN PEREIRA RIBEIRO; LUÍS CARLOS DE SOUZA FERREIRA; JORGE KALIL; DANIELA SANTORO ROSA; EDECIO CUNHA NETO. Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 1010-1016, 2015-11-24. (04/15856-9, 06/50096-0, 08/57881-0)

CARVALHO, KARINA I.; BRUNO, FERNANDA R.; SNYDER-CAPPIONE, JENNIFER E.; MAEDA, SOLANGE M.; TOMIMORI, JANE; XAVIER, MARILIA B.; HASLETT, PATRICK A.; NIXON, DOUGLAS F.; KALLAS, ESPER G.. Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. IMMUNOLOGY, v. 136, n. 1, p. 96-102, MAY 2012. (04/15856-9, 10/05845-0)

ARARIPE SUCUPIRA, MARIA CECILIA; SANABANI, SABRI; CORTES, RODRIGO M.; GIRET, MARIA TERESA M.; TOMIYAMA, HELENA; SAUER, MARIANA M.; SABINO, ESTER CERDEIRA; JANINI, LUIZ MARIO; KALLAS, ESPER GEORGES; DIAZ, RICARDO SOBHIE. Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains. PLoS One, v. 7, n. 1, JAN 26 2012. (04/15856-9)

ALENCAR, CECILIA S.; NISHIYA, ANNA S.; FERREIRA, SUZETE; GIRET, MARIA TERESA M.; DIAZ, RICARDO S.; SABINO, ESTER C.. Evaluation of Primary Resistance to HIV Entry Inhibitors Among Brazilian Patients Failing Reverse Transcriptase/Protease Inhibitors Treatment Reveal High Prevalence of Maraviroc Resistance-Related Mutations. AIDS Research and Human Retroviruses, v. 26, n. 12, p. 1267-1271, DEC 2010. (04/15856-9)

TAROSSO, LEANDRO F.; SAUER, MARIANA M.; SANABANI, SABRI; GIRET, MARIA TERESA; TOMIYAMA, HELENA I.; SIDNEY, JOHN; PIASKOWSKI, SHARI M.; DIAZ, RICARDO S.; SABINO, ESTER C.; SETTE, ALESSANDRO; et al. Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication. PLoS One, v. 5, n. 7, JUL 2 2010. (04/15856-9)

KIESSLICH, DAGMAR; CRISPIM, MYUKI ALFAIA; SANTOS, CARLOS; FERREIRA, FERNANDO DE LIMA; FRAIJI, NELSON ABRAHIM; KOMNINAKIS, SHIRLEY VASCONCELOS; DIAZ, RICARDO SOBHIE. Influence of Hepatitis B Virus (HBV) Genotype on the Clinical Course of Disease in Patients Coinfected with HBV and Hepatitis Delta Virus. Journal of Infectious Diseases, v. 199, n. 11, p. 1608-1611, JUN 1 2009. (04/15856-9)

BARBOUR, JASON D.; SAUER, MARIANA M.; SHARP, ELIZABETH R.; GARRISON, KEITH E.; LONG, BRIAN R.; TOMIYAMA, HELENA; BASSICHETTO, KATIA C.; OLIVEIRA, SOLANGE M.; ABBATE, MARIA C.; NIXON, DOUGLAS F.; et al. HIV-1/HSV-2 Co-Infected Adults in Early HIV-1 Infection Have Elevated CD4+T Cell Counts. PLoS One, v. 2, n. 10, OCT 24 2007. (04/15856-9)

SOARES DE OLIVEIRA, ANA CAROLINA; DE FARIAS, RODRIGO PESSOA; DA COSTA, ANTONIO CHARLYS; SAUER, MARIANA MELILLO; BASSICHETTO, KATIA CRISTINA; SANTOS OLIVEIRA, SOLANGE MARIA; COSTA, PRISCILLA RAMOS; TOMIYAMA, CLAUDIA; IWASHITA TOMIYAMA, HELENA TOMOKO; SABINO, ESTER CERDEIRA; et al. Frequency of subtype B and F1 dual infection in HIV-1 positive, Brazilian men who have sex with men. VIROLOGY JOURNAL, v. 9, SEP 29 2012. (04/15856-9)

BIMBER, BENJAMIN N.; DUDLEY, DAWN M.; LAUCK, MICHAEL; BECKER, ERICKA A.; CHIN, EMILY N.; LANK, SIMON M.; GRUNENWALD, HAIYING L.; CARUCCIO, NICHOLAS C.; MAFFITT, MARK; WILSON, NANCY A.; et al. Whole-Genome Characterization of Human and Simian Immunodeficiency Virus Intrahost Diversity by Ultradeep Pyrosequencing. Journal of Virology, v. 84, n. 22, p. 12087-12092, NOV 2010. (04/15856-9)

ALMEIDA, RAFAEL RIBEIRO; RAPOSO, RUI ANDRE SARAIVA; COIRADA, FERNANDA CAROLINE; DA SILVA, JAMILE RAMOS; DE SOUZA FERREIRA, LUIS CARLOS; KALIL, JORGE; NIXON, DOUGLAS F.; CUNHA-NETO, EDECIO. Modulating APOBEC expression enhances DNA vaccine immunogenicity. Immunology and Cell Biology, v. 93, n. 10, p. 868-876, NOV 2015. (08/57881-0, 06/50096-0, 04/15856-9)

TEIXEIRA, DANIELA; MUNERATO, PATRICIA; VASCONCELOS KOMNINAKIS, SHIRLEY CAVALCANTE; FUSUMA, ERIKA ETSUKO; JANINI, LUIZ MARIO; ARARIPE SUCUPIRA, MARIA CECILIA; DIAZ, RICARDO SOBHIE. The Detection of in Vivo and in Vitro HIV Type 1 B/F Profiles in Brazil Using a Real-Time PCR Assay for Five HIV Type 1 Genomic Regions. AIDS Research and Human Retroviruses, v. 26, n. 9, p. 981-990, SEP 2010. (04/15856-9)

DUDLEY, DAWN M.; CHIN, EMILY N.; BIMBER, BENJAMIN N.; SANABANI, SABRI S.; TAROSSO, LEANDRO F.; COSTA, PRISCILLA R.; SAUER, MARIANA M.; KALLAS, ESPER G.; O'CONNOR, DAVID H.. Low-Cost Ultra-Wide Genotyping Using Roche/454 Pyrosequencing for Surveillance of HIV Drug Resistance. PLoS One, v. 7, n. 5, MAY 4 2012. (04/15856-9, 06/50096-0)

HOLDITCH, SARA J.; ERIKSSON, EMILY M.; TAROSSO, LEANDRO F.; KUEBLER, PETER J.; KALLAS, ESPER G.; NIELSEN, ERIK K.; WIZNIA, ANDREW A.; ROSENBERG, MICHAEL G.; NIXON, DOUGLAS F.. Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants. FRONTIERS IN IMMUNOLOGY, v. 2, 2012. (04/15856-9, 10/05845-0)

PAQUIN-PROULX, DOMINIC; BARSOTTI, NATHALIA SILVEIRA; SANTOS, BIANCA A. N.; MARINHO, ANA KAROLINA B. B.; KOKRON, CRISTINA M.; CARVALHO, KARINA I.; BARROS, MYRTHES T.; KALIL, JORGE; NIXON, DOUGLAS F.; KALLAS, ESPER G.. Inversion of the V delta 1 to V delta 2 gamma delta T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion. MEDICINE, v. 95, n. 30, JUL 2016. (04/15856-9, 10/05845-0)

BASSICHETTO, KATIA CRISTINA; BERGAMASCHI, DENISE PIMENTEL; OLIVEIRA, SOLANGE MARIA; VERRI DEIENNO, MARYLEI CASTELDELLI; BORTOLATO, REGINALDO; DE REZENDE, HELOIZA VILMA; ARTHUR, THAIS; TOMIYAMA, HELENA; WATKINS, COLYN; MESQUITA, FABIO; et al. Elevated Risk for HIV-1 Infection in Adolescents and Young Adults in Sao Paulo, Brazil. PLoS One, v. 3, n. 1, p. 0-0, Jan. 2008. (04/15856-9)

SANABANI‚ S.S.; PASTENA‚ ER; NETO‚ W.K.; MARTINEZ‚ V.P.; SABINO‚ E.C.; OTHERS. Characterization and frequency of a newly identified HIV-1 BF1 intersubtype circulating recombinant form in Sao Paulo‚ Brazil. VIROLOGY JOURNAL, v. 7, p. 74, 2010. (04/15856-9, 06/50096-0, 07/04890-0)

SANABANI‚ S.S.; DE SOUZA PASTENA‚ É.R.; DA COSTA‚ A.C.; MARTINEZ‚ V.P.; KLEINE-NETO‚ W.; DE OLIVEIRA‚ A.C.S.; SAUER‚ M.M.; BASSICHETTO‚ K.C.; OLIVEIRA‚ S.M.S.; TOMIYAMA‚ H.T.I.; et al. Characterization of partial and near full-length genomes of HIV-1 strains sampled from recently infected individuals in Sao Paulo‚ Brazil. PLoS One, v. 6, n. 10, p. e25869, 2011. (04/15856-9, 06/50096-0)

SANABANI, SABRI SAEED; DE SOUZA PASTENA, EVELYN REGINA; KLEINE NETO, WALTER; MARTINEZ, VANESSA POUZA; SABINO, ESTER CERDEIRA. Characterization and frequency of a newly identified HIV-1 BF1 intersubtype circulating recombinant form in Sao Paulo, Brazil. VIROLOGY JOURNAL, v. 7, APR 16 2010. (04/15856-9, 06/50096-0, 07/04890-0)

SANABANI, SABRI SAEED; DE SOUZA PASTENA, EVELYN REGINA; DA COSTA, ANTONIO CHARLYS; MARTINEZ, VANESSA POUZA; KLEINE-NETO, WALTER; SOARES DE OLIVEIRA, ANA CAROLINA; SAUER, MARIANA MELILLO; BASSICHETTO, KATIA CRISTINA; SANTOS OLIVEIRA, SOLANGE MARIA; IWASHITA TOMIYAMA, HELENA TOMOKO; et al. Characterization of Partial and Near Full-Length Genomes of HIV-1 Strains Sampled from Recently Infected Individuals in Sao Paulo, Brazil. PLoS One, v. 6, n. 10, OCT 14 2011. (04/15856-9, 06/50096-0)

PAQUIN-PROULX, D.; CHING, C.; VUJKOVIC-CVIJIN, I.; FADROSH, D.; LOH, L.; HUANG, Y.; SOMSOUK, M.; LYNCH, S. V.; HUNT, P. W.; NIXON, D. F.; et al. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection. MUCOSAL IMMUNOLOGY, v. 10, n. 1, p. 69-78, JAN 2017. (04/15856-9, 10/05845-0)

BATISTA, MARIANA D.; TINCATI, CAMILLA; MILUSH, JEFFREY M.; HO, EMILY L.; NDHLOVU, LISHOMWA C.; YORK, VANESSA A.; KALLAS, ESPER G.; KALIL, JORGE; KEATING, SHEILA M.; NORRIS, PHILIP J.; et al. CD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis. PLoS One, v. 8, n. 2, FEB 28 2013. (04/15856-9, 10/05845-0)

LEAL, FABIO E.; NDHLOVU, LISHOMWA C.; HASENKRUG, AARON M.; BRUNO, FERNANDA R.; CARVALHO, KARINA I.; WYNN-WILLIAMS, HARRY; NETO, WALTER K.; SANABANI, SABRI S.; SEGURADO, ALUISIO C.; NIXON, DOUGLAS F.; et al. Expansion in CD39(+) CD4(+) Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications. PLoS Neglected Tropical Diseases, v. 7, n. 2, FEB 2013. (04/15856-9, 10/05845-0, 11/12297-2)

MAHNKE, YOLANDA D.; SONG, KAIMEI; SAUER, MARIANA M.; NASON, MARTHA C.; GIRET, MARIA TERESA M.; CARVALHO, KARINA I.; COSTA, PRISCILLA R.; ROEDERER, MARIO; KALLAS, ESPER G.. Early immunologic and virologic predictors of clinical HIV-1 disease progression. AIDS, v. 27, n. 5, p. 697-706, MAR 13 2013. (04/15856-9, 06/50096-0)

LEAL, FABIO E.; MENEZES, SORAYA MARIA; COSTA, EMANUELA A. S.; BRAILEY, PHILLIP M.; GAMA, LUCIO; SEGURADO, ALUISIO C.; KALLAS, ESPER G.; NIXON, DOUGLAS F.; DIERCKX, TIM; KHOURI, RICARDO; et al. Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-beta Response in HTLV-1-Associated Neuroinflammation. FRONTIERS IN MICROBIOLOGY, v. 9, MAY 22 2018. (04/15856-9, 10/05845-0)

VERGARA, TANIA R. C.; SAMER, SADIA; SANTOS-OLIVEIRA, JOANNA R.; GIRON, LEILA B.; ARIF, MUHAMMAD SHOAIB; SILVA-FREITAS, MARIA LUCIANA; CHERMAN, LIA A.; TREITSMAN, MAURO S.; CHEBABO, ALBERTO; SUCUPIRA, MARIA CECILIA A.; et al. Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety. EBIOMEDICINE, v. 23, p. 59-67, SEP 2017. (04/15856-9)

SANTANA, VINICIUS CANATO; ALMEIDA, RAFAEL RIBEIRO; RIBEIRO, SUSAN PEREIRA; DE SOUZA FERREIRA, LIUS CARLOS; KALIL, JORGE; ROSA, DANIELA SANTORO; CUNHA-NETO, EDECIO. Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4(+) T-cell responses. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 1010-1016, DEC 2015. (08/57881-0, 06/50096-0, 04/15856-9)

JONES, R.; LEAL, FABIO; HASENKRUG, AARON; SEGURADO, ALUISIO; NIXON, DOUGLAS; OSTROWSKI, MARIO; KALLAS, ESPER. Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV- I- infected subjects using standard peptide screening methods. JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE, v. 12, p. 6-pg., 2013-01-01. (10/05845-0, 04/15856-9)

BERMUDEZ-AZA, ELKIN HERNAN; FRANCO SANSIGOLO KERR, LIGIA REGINA; KENDALL, CARL; PINHO, ADRIANA ARAUJO; DE MELLO, MAEVE BRITO; MOTA, ROSA SALANI; CROSLAND GUIMARAES, MARK DREW; ALENCAR, CECILIA SALETE; DE BRITO, ANA MARIA; DOURADO, INES COSTA; et al. Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v. 57, p. 7-pg., 2011-08-15. (04/15856-9)

KUEBLER, PETER J.; MEHROTRA, MEGHA L.; MCCONNELL, J. JEFF; HOLDITCH, SARA J.; SHAW, BRIAN I.; TAROSSO, LEANDRO F.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; RAPOSO, RUI ANDRE SARAIVA; et al. Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 112, n. 27, p. 6-pg., 2015-07-07. (10/05845-0, 04/15856-9)