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Prevalence of HIV-1 tropic variants in a cohort of HIV-1 recently infected individuals from the state of São Paulo

Grant number: 07/04918-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2007
Effective date (End): February 29, 2008
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Ester Cerdeira Sabino
Grantee:Ana Maria Barros de Carvalho
Home Institution: Hemocentro de São Paulo. Fundação Pró-Sangue. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos, AP.TEM

Abstract

RESUME Background: Expression of HIV-1 coreceptors on the surface of various human cells is believed to influence the dynamics of viral tropism throughout the course of HIV-1 infection. There is a concern that CXCR4 co-receptor usage could provide an advantage for replication and transmission to drug-resistant strains. In this study we aimed to determine the prevalence of virus co-receptor usage in a cohort of recent HIV seroconverters in São Paulo, Brazil, and HIV subtypes.Methods: Genomic DNA will be exracted from blood samples of 110 HIV-1seroconverter. V3 loop amino acid sequences at the time of initial diagnosis will be analysed for prediction of coreceptor usage.