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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants

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Holditch, Sara J. [1] ; Eriksson, Emily M. [1] ; Tarosso, Leandro F. [2] ; Kuebler, Peter J. [1] ; Kallas, Esper G. [2] ; Nielsen, Erik K. [3] ; Wiznia, Andrew A. [3] ; Rosenberg, Michael G. [3] ; Nixon, Douglas F. [1]
Total Authors: 9
[1] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, Div Expt Med, San Francisco, CA - USA
[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo - Brazil
[3] Albert Einstein Coll Med, Jacobi Med Ctr, Bronx, NY 10467 - USA
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN IMMUNOLOGY; v. 2, 2012.
Web of Science Citations: 4

Objective: The majority of infants born, in developed countries, to HIV-1 positive women are exposed to the HIV-1 virus in utero or peri/post-partum, but are born uninfected.We, and others, have previously shown HIV-1 specific T cell responses in HIV-1 exposed seronegative (HESN) neonates/infants. Our objective in this study was to examine the rate of decay in their HIV-1 specific T cell response over time from birth. Design: Cross-sectional and longitudinal studies of HIV-1 specific T cell responses in HESN infants were performed. Methods: Peripheral blood mononuclear cells (PBMC) were isolated from 18 HIV-1 DNA PCR negative infants born to HIV-1 infected mothers receiving care at the Jacobi Medical Center, Bronx, NY, USA. PBMC were examined for T cell responses to HIV-1 antigens by interferon-gamma (IFN-gamma) ELISPOT. Results: PBMC from 15 HESN neonates/infants were analyzed. We observed a decay of HIV-1 specific T cell responses from birth at a rate of -0.599 spot forming unit/10(6) cells per day, with a median half-life decay rate of 21.38 weeks (13.39-115.8). Conclusion: Our results support the dynamic nature of T cell immunity in the context of a developing immune system. The disparate rate of decay with studies of adults placed on antiretroviral drugs suggests that antigen specific T cell responses are driven by the natural rate of decay of the T cell sub-populations themselves. (AU)

FAPESP's process: 10/05845-0 - Cellular immune responses in infectious diseases and primary immunodeficiencies
Grantee:Esper Georges Kallás
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos
Grantee:Ricardo Sobhie Diaz
Support type: Research Projects - Thematic Grants