| Full text | |
| Author(s): |
Holditch, Sara J.
[1]
;
Eriksson, Emily M.
[1]
;
Tarosso, Leandro F.
[2]
;
Kuebler, Peter J.
[1]
;
Kallas, Esper G.
[2]
;
Nielsen, Erik K.
[3]
;
Wiznia, Andrew A.
[3]
;
Rosenberg, Michael G.
[3]
;
Nixon, Douglas F.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, Div Expt Med, San Francisco, CA - USA
[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo - Brazil
[3] Albert Einstein Coll Med, Jacobi Med Ctr, Bronx, NY 10467 - USA
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | FRONTIERS IN IMMUNOLOGY; v. 2, 2012. |
| Web of Science Citations: | 4 |
| Abstract | |
Objective: The majority of infants born, in developed countries, to HIV-1 positive women are exposed to the HIV-1 virus in utero or peri/post-partum, but are born uninfected.We, and others, have previously shown HIV-1 specific T cell responses in HIV-1 exposed seronegative (HESN) neonates/infants. Our objective in this study was to examine the rate of decay in their HIV-1 specific T cell response over time from birth. Design: Cross-sectional and longitudinal studies of HIV-1 specific T cell responses in HESN infants were performed. Methods: Peripheral blood mononuclear cells (PBMC) were isolated from 18 HIV-1 DNA PCR negative infants born to HIV-1 infected mothers receiving care at the Jacobi Medical Center, Bronx, NY, USA. PBMC were examined for T cell responses to HIV-1 antigens by interferon-gamma (IFN-gamma) ELISPOT. Results: PBMC from 15 HESN neonates/infants were analyzed. We observed a decay of HIV-1 specific T cell responses from birth at a rate of -0.599 spot forming unit/10(6) cells per day, with a median half-life decay rate of 21.38 weeks (13.39-115.8). Conclusion: Our results support the dynamic nature of T cell immunity in the context of a developing immune system. The disparate rate of decay with studies of adults placed on antiretroviral drugs suggests that antigen specific T cell responses are driven by the natural rate of decay of the T cell sub-populations themselves. (AU) | |
| FAPESP's process: | 04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos |
| Grantee: | Ricardo Sobhie Diaz |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 10/05845-0 - Cellular immune responses in infectious diseases and primary immunodeficiencies |
| Grantee: | Esper Georges Kallás |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |