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Cellular immune responses in infectious diseases and primary immunodeficiencies

Grant number: 10/05845-0
Support type:Research Grants - Visiting Researcher Grant - International
Duration: July 24, 2010 - August 30, 2011
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Esper Georges Kallás
Grantee:Esper Georges Kallás
Visiting researcher: Douglas Fraser Nixon
Visiting researcher institution: University of California, San Francisco (UCSF), United States
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

After continuous collaboration with the Graduate Programs at the School of Medicine, University of São Paulo, Dr. Douglas Nixon, Professor at the Department of Experimental Medicine, University of California, San Francisco, must comply with activities such as Visiting Scientist in the Department of Clinical Immunology and Allergy. The activities should be developed in 2010, with support of the University of Sao Paulo. The activities will involve the areas of Graduate, Research and interaction with the Institute of Research in Immunology, which was recently approved for funding as a National Institutes of Science and Technology by CNPq, under the direction of Prof. Dr. Jorge Kalil Filho. The activities of Dr. Douglas Nixon will be distributed in four annual visits of a month duration each and the cost of tickets will be financed by FAPESP as requested and the three other resources from the projects of Dr. Nixon. The dates are: Visit 1 - July 24 to August 20, 2010Visit 2 - October 15 to November 11, 2010 Visit 3 - February 5 to March 4, 2011Visit 4 - June 1 to June 30, 2011Professor. Nixon will assist in the implementation of three courses of graduate in the program of Allergy and Immunology: 1 - II Course of Writing Scientific Papers and Projects. 2- 19 August 20102 - II Course of HIV: Gender, Society and Science. 25 October-4 November 2010. 3 - VI Advanced Course in HIV Pathogenesis. 21-25 February 2011. Prof. Douglas Nixon will also attend the aforementioned course for the year 2010. The course schedule for the year 2010 is attached. http://patogenesehiv2010.iii.org.br/patogenesehiv2010/index.htmlIn the same month of February, Professor D. Nixon will provide assistance in the context of scientific exchange program for students (Students Exchange Program) that it keeps with the research group of Prof. Esper Kallas since 2002. 4 - Development of New Projects and Participation in series of Conferences "Frontiers of Medicine", June 2011. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Study indicates that HIV has genetic diversity in São Paulo 

Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEAL, FABIO E.; MENEZES, SORAYA MARIA; COSTA, EMANUELA A. S.; BRAILEY, PHILLIP M.; GAMA, LUCIO; SEGURADO, ALUISIO C.; KALLAS, ESPER G.; NIXON, DOUGLAS F.; DIERCKX, TIM; KHOURI, RICARDO; VERCAUTEREN, JURGEN; GALVAO-CASTRO, BERNARDO; SARAIVA RAPOSO, RUI ANDRE; VAN WEYENBERGH, JOHAN. Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-beta Response in HTLV-1-Associated Neuroinflammation. FRONTIERS IN MICROBIOLOGY, v. 9, MAY 22 2018. Web of Science Citations: 1.
PAQUIN-PROULX, D.; CHING, C.; VUJKOVIC-CVIJIN, I.; FADROSH, D.; LOH, L.; HUANG, Y.; SOMSOUK, M.; LYNCH, S. V.; HUNT, P. W.; NIXON, D. F.; SENGUPTA, D. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection. MUCOSAL IMMUNOLOGY, v. 10, n. 1, p. 69-78, JAN 2017. Web of Science Citations: 18.
RIBEIRO, SUSAN PEREIRA; MILUSH, JEFFREY M.; CUNHA-NETO, EDECIO; KALLAS, ESPER G.; KALIL, JORGE; PASSERO, LUIZ FELIPE D.; HUNT, PETER W.; DEEKS, STEVEN G.; NIXON, DOUGLAS F.; SENGUPTA, DEVI. p16(INK4a) Expression and Immunologic Aging in Chronic HIV Infection. PLoS One, v. 11, n. 11 NOV 18 2016. Web of Science Citations: 3.
PAQUIN-PROULX, DOMINIC; BARSOTTI, NATHALIA SILVEIRA; SANTOS, BIANCA A. N.; MARINHO, ANA KAROLINA B. B.; KOKRON, CRISTINA M.; CARVALHO, KARINA I.; BARROS, MYRTHES T.; KALIL, JORGE; NIXON, DOUGLAS F.; KALLAS, ESPER G. Inversion of the V delta 1 to V delta 2 gamma delta T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion. MEDICINE, v. 95, n. 30 JUL 2016. Web of Science Citations: 3.
KUEBLER, PETER J.; SHAW, BRIAN I.; LEADABRAND, KAITLYN S.; MEHROTRA, MEGHA L.; GRANT, ROBERT M.; KALLAS, ESPER G.; NIXON, DOUGLAS F. HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v. 72, n. 2, p. 184-188, JUN 1 2016. Web of Science Citations: 1.
KUEBLER, PETER J.; MEHROTRA, MEGHA L.; SHAW, BRIAN I.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; DEFECHEREUX, PATRICIA; GRANT, ROBERT M.; KALLAS, ESPER G.; NIXON, DOUGLAS F. Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8(+) T-Cell Activation. Journal of Infectious Diseases, v. 213, n. 4, p. 569-573, FEB 15 2016. Web of Science Citations: 5.
KUEBLER, PETER J.; MEHROTRA, MEGHA L.; MCCONNELL, J. JEFF; HOLDITCH, SARA J.; SHAW, BRIAN I.; TAROSSO, LEANDRO F.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; RAPOSO, RUI ANDRE SARAIVA; CHENG, REX G.; ERIKSSON, EMILY M.; MCMAHAN, VANESSA; GLIDDEN, DAVID V.; SHIBOSKI, STEPHEN; GRANT, ROBERT M.; NIXON, DOUGLAS F.; KALLAS, ESPER G. Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 27, p. 8379-8384, JUL 7 2015. Web of Science Citations: 10.
RIBEIRO, SUSAN P.; MILUSH, JEFFREY M.; CUNHA-NETO, EDECIO; KALLAS, ESPER G.; KALIL, JORGE; SOMSOUK, MA; HUNT, PETER W.; DEEKS, STEVEN G.; NIXON, DOUGLAS F.; SENGUPTA, DEVI. The CD8(+) Memory Stem T Cell (T-SCM) Subset Is Associated with Improved Prognosis in Chronic HIV-1 Infection. Journal of Virology, v. 88, n. 23, p. 13836-13844, DEC 2014. Web of Science Citations: 16.
SANABANI, SABRI SAEED; PESSOA, RODRIGO; SOARES DE OLIVEIRA, ANA CAROLINA; MARTINEZ, VANESSA POUZA; GIRET, MARIA TERESA MAIDANA; DE MENEZES SUCCI, REGINA CELIA; CARVALHO, KARINA; TOMIYAMA, CLAUDIA SATIKO; NIXON, DOUGLAS F.; SABINO, ESTER CERDEIRA; KALLAS, ESPER GEORGES. Variability of HIV-1 Genomes among Children and Adolescents from Sao Paulo, Brazil. PLoS One, v. 8, n. 5 MAY 7 2013. Web of Science Citations: 15.
BATISTA, MARIANA D.; TINCATI, CAMILLA; MILUSH, JEFFREY M.; HO, EMILY L.; NDHLOVU, LISHOMWA C.; YORK, VANESSA A.; KALLAS, ESPER G.; KALIL, JORGE; KEATING, SHEILA M.; NORRIS, PHILIP J.; CHANG, DAVID; UNEMORI, PATRICK; LESLIE, KIERON S.; MAURER, TOBY; LIAO, WILSON; NIXON, DOUGLAS F. CD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis. PLoS One, v. 8, n. 2 FEB 28 2013. Web of Science Citations: 4.
LEAL, FABIO E.; NDHLOVU, LISHOMWA C.; HASENKRUG, AARON M.; BRUNO, FERNANDA R.; CARVALHO, KARINA I.; WYNN-WILLIAMS, HARRY; NETO, WALTER K.; SANABANI, SABRI S.; SEGURADO, ALUISIO C.; NIXON, DOUGLAS F.; KALLAS, ESPER G. Expansion in CD39(+) CD4(+) Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications. PLoS Neglected Tropical Diseases, v. 7, n. 2 FEB 2013. Web of Science Citations: 9.
CARVALHO, KARINA I.; BRUNO, FERNANDA R.; SNYDER-CAPPIONE, JENNIFER E.; MAEDA, SOLANGE M.; TOMIMORI, JANE; XAVIER, MARILIA B.; HASLETT, PATRICK A.; NIXON, DOUGLAS F.; KALLAS, ESPER G. Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. IMMUNOLOGY, v. 136, n. 1, p. 96-102, MAY 2012. Web of Science Citations: 3.
HOLDITCH, SARA J.; ERIKSSON, EMILY M.; TAROSSO, LEANDRO F.; KUEBLER, PETER J.; KALLAS, ESPER G.; NIELSEN, ERIK K.; WIZNIA, ANDREW A.; ROSENBERG, MICHAEL G.; NIXON, DOUGLAS F. Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants. FRONTIERS IN IMMUNOLOGY, v. 2, 2012. Web of Science Citations: 5.
NDHLOVU, LISHOMWA C.; LEAL, FABIO E.; HASENKRUG, AARON M.; JHA, AASHISH R.; CARVALHO, KARINA I.; ECCLES-JAMES, IJEOMA G.; BRUNO, FERNANDA R.; VIEIRA, RAPHAELLA G. S.; YORK, VANESSA A.; CHEW, GLEN M.; JONES, R. BRAD; TANAKA, YUETSU; NETO, WALTER K.; SANABANI, SABRI S.; OSTROWSKI, MARIO A.; SEGURADO, ALUISIO C.; NIXON, DOUGLAS F.; KALLAS, ESPER G. HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications. PLOS NEGLECTED TROPICAL DISEASES, v. 5, n. 4 APR 2011. Web of Science Citations: 13.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.