Cellular immune responses in infectious diseases and primary immunodeficiencies

• Grant number: 10/05845-0
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Duration: July 24, 2010 - August 30, 2011
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Esper Georges Kallás
• Grantee: Esper Georges Kallás
• Visiting researcher: Douglas Fraser Nixon
• Visiting researcher institution: University of California, San Francisco (UCSF), United States
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

After continuous collaboration with the Graduate Programs at the School of Medicine, University of São Paulo, Dr. Douglas Nixon, Professor at the Department of Experimental Medicine, University of California, San Francisco, must comply with activities such as Visiting Scientist in the Department of Clinical Immunology and Allergy. The activities should be developed in 2010, with support of the University of Sao Paulo. The activities will involve the areas of Graduate, Research and interaction with the Institute of Research in Immunology, which was recently approved for funding as a National Institutes of Science and Technology by CNPq, under the direction of Prof. Dr. Jorge Kalil Filho. The activities of Dr. Douglas Nixon will be distributed in four annual visits of a month duration each and the cost of tickets will be financed by FAPESP as requested and the three other resources from the projects of Dr. Nixon. The dates are: Visit 1 - July 24 to August 20, 2010Visit 2 - October 15 to November 11, 2010 Visit 3 - February 5 to March 4, 2011Visit 4 - June 1 to June 30, 2011Professor. Nixon will assist in the implementation of three courses of graduate in the program of Allergy and Immunology: 1 - II Course of Writing Scientific Papers and Projects. 2- 19 August 20102 - II Course of HIV: Gender, Society and Science. 25 October-4 November 2010. 3 - VI Advanced Course in HIV Pathogenesis. 21-25 February 2011. Prof. Douglas Nixon will also attend the aforementioned course for the year 2010. The course schedule for the year 2010 is attached. http://patogenesehiv2010.iii.org.br/patogenesehiv2010/index.htmlIn the same month of February, Professor D. Nixon will provide assistance in the context of scientific exchange program for students (Students Exchange Program) that it keeps with the research group of Prof. Esper Kallas since 2002. 4 - Development of New Projects and Participation in series of Conferences "Frontiers of Medicine", June 2011. (AU)

Scientific publications

(17)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KUEBLER, PETER J.; MEHROTRA, MEGHA L.; MCCONNELL, J. JEFF; HOLDITCH, SARA J.; SHAW, BRIAN I.; TAROSSO, LEANDRO F.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; RAPOSO, RUI ANDRE SARAIVA; et al. Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 27, p. 8379-8384, JUL 7 2015. (04/15856-9, 10/05845-0)

NDHLOVU, LISHOMWA C.; LEAL, FABIO E.; HASENKRUG, AARON M.; JHA, AASHISH R.; CARVALHO, KARINA I.; ECCLES-JAMES, IJEOMA G.; BRUNO, FERNANDA R.; VIEIRA, RAPHAELLA G. S.; YORK, VANESSA A.; CHEW, GLEN M.; et al. HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications. PLOS NEGLECTED TROPICAL DISEASES, v. 5, n. 4, APR 2011. (10/05845-0)

HOLDITCH, SARA J.; ERIKSSON, EMILY M.; TAROSSO, LEANDRO F.; KUEBLER, PETER J.; KALLAS, ESPER G.; NIELSEN, ERIK K.; WIZNIA, ANDREW A.; ROSENBERG, MICHAEL G.; NIXON, DOUGLAS F.. Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants. FRONTIERS IN IMMUNOLOGY, v. 2, 2012. (04/15856-9, 10/05845-0)

PAQUIN-PROULX, DOMINIC; BARSOTTI, NATHALIA SILVEIRA; SANTOS, BIANCA A. N.; MARINHO, ANA KAROLINA B. B.; KOKRON, CRISTINA M.; CARVALHO, KARINA I.; BARROS, MYRTHES T.; KALIL, JORGE; NIXON, DOUGLAS F.; KALLAS, ESPER G.. Inversion of the V delta 1 to V delta 2 gamma delta T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion. MEDICINE, v. 95, n. 30, JUL 2016. (04/15856-9, 10/05845-0)

LEAL, FABIO E.; MENEZES, SORAYA MARIA; COSTA, EMANUELA A. S.; BRAILEY, PHILLIP M.; GAMA, LUCIO; SEGURADO, ALUISIO C.; KALLAS, ESPER G.; NIXON, DOUGLAS F.; DIERCKX, TIM; KHOURI, RICARDO; et al. Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-beta Response in HTLV-1-Associated Neuroinflammation. FRONTIERS IN MICROBIOLOGY, v. 9, MAY 22 2018. (04/15856-9, 10/05845-0)

BATISTA, MARIANA D.; TINCATI, CAMILLA; MILUSH, JEFFREY M.; HO, EMILY L.; NDHLOVU, LISHOMWA C.; YORK, VANESSA A.; KALLAS, ESPER G.; KALIL, JORGE; KEATING, SHEILA M.; NORRIS, PHILIP J.; et al. CD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis. PLoS One, v. 8, n. 2, FEB 28 2013. (04/15856-9, 10/05845-0)

LEAL, FABIO E.; NDHLOVU, LISHOMWA C.; HASENKRUG, AARON M.; BRUNO, FERNANDA R.; CARVALHO, KARINA I.; WYNN-WILLIAMS, HARRY; NETO, WALTER K.; SANABANI, SABRI S.; SEGURADO, ALUISIO C.; NIXON, DOUGLAS F.; et al. Expansion in CD39(+) CD4(+) Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications. PLoS Neglected Tropical Diseases, v. 7, n. 2, FEB 2013. (04/15856-9, 10/05845-0, 11/12297-2)

CARVALHO, KARINA I.; BRUNO, FERNANDA R.; SNYDER-CAPPIONE, JENNIFER E.; MAEDA, SOLANGE M.; TOMIMORI, JANE; XAVIER, MARILIA B.; HASLETT, PATRICK A.; NIXON, DOUGLAS F.; KALLAS, ESPER G.. Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. IMMUNOLOGY, v. 136, n. 1, p. 96-102, MAY 2012. (04/15856-9, 10/05845-0)

KUEBLER, PETER J.; MEHROTRA, MEGHA L.; MCCONNELL, J. JEFF; HOLDITCH, SARA J.; SHAW, BRIAN I.; TAROSSO, LEANDRO F.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; RAPOSO, RUI ANDRE SARAIVA; et al. Cellular immune correlates analysis of an HIV-1 preexposure prophylaxis trial. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 112, n. 27, p. 6-pg., 2015-07-07. (10/05845-0, 04/15856-9)

PAQUIN-PROULX, D.; CHING, C.; VUJKOVIC-CVIJIN, I.; FADROSH, D.; LOH, L.; HUANG, Y.; SOMSOUK, M.; LYNCH, S. V.; HUNT, P. W.; NIXON, D. F.; et al. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection. MUCOSAL IMMUNOLOGY, v. 10, n. 1, p. 69-78, JAN 2017. (04/15856-9, 10/05845-0)

JONES, R.; LEAL, FABIO; HASENKRUG, AARON; SEGURADO, ALUISIO; NIXON, DOUGLAS; OSTROWSKI, MARIO; KALLAS, ESPER. Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV- I- infected subjects using standard peptide screening methods. JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE, v. 12, p. 6-pg., 2013-01-01. (10/05845-0, 04/15856-9)

RIBEIRO, SUSAN PEREIRA; MILUSH, JEFFREY M.; CUNHA-NETO, EDECIO; KALLAS, ESPER G.; KALIL, JORGE; PASSERO, LUIZ FELIPE D.; HUNT, PETER W.; DEEKS, STEVEN G.; NIXON, DOUGLAS F.; SENGUPTA, DEVI. p16(INK4a) Expression and Immunologic Aging in Chronic HIV Infection. PLoS One, v. 11, n. 11, NOV 18 2016. (10/05845-0)

KUEBLER, PETER J.; SHAW, BRIAN I.; LEADABRAND, KAITLYN S.; MEHROTRA, MEGHA L.; GRANT, ROBERT M.; KALLAS, ESPER G.; NIXON, DOUGLAS F.. HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v. 72, n. 2, p. 184-188, JUN 1 2016. (04/15856-9, 10/05845-0)

RIBEIRO, SUSAN P.; MILUSH, JEFFREY M.; CUNHA-NETO, EDECIO; KALLAS, ESPER G.; KALIL, JORGE; SOMSOUK, MA; HUNT, PETER W.; DEEKS, STEVEN G.; NIXON, DOUGLAS F.; SENGUPTA, DEVI. The CD8(+) Memory Stem T Cell (T-SCM) Subset Is Associated with Improved Prognosis in Chronic HIV-1 Infection. Journal of Virology, v. 88, n. 23, p. 13836-13844, DEC 2014. (10/05845-0)

SANABANI, SABRI SAEED; PESSOA, RODRIGO; SOARES DE OLIVEIRA, ANA CAROLINA; MARTINEZ, VANESSA POUZA; GIRET, MARIA TERESA MAIDANA; DE MENEZES SUCCI, REGINA CELIA; CARVALHO, KARINA; TOMIYAMA, CLAUDIA SATIKO; NIXON, DOUGLAS F.; SABINO, ESTER CERDEIRA; et al. Variability of HIV-1 Genomes among Children and Adolescents from Sao Paulo, Brazil. PLoS One, v. 8, n. 5, MAY 7 2013. (11/09983-1, 04/15856-9, 06/50096-0, 10/05845-0)

NDHLOVU, LISHOMWA C.; LEAL, FABIO E.; HASENKRUG, AARON M.; JHA, AASHISH R.; CARVALHO, KARINA I.; ECCLES-JAMES, IJEOMA G.; BRUNO, FERNANDA R.; VIEIRA, RAPHAELLA G. S.; YORK, VANESSA A.; CHEW, GLEN M.; et al. HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications. PLoS Neglected Tropical Diseases, v. 5, n. 4, p. 9-pg., 2011-04-01. (10/05845-0)

KUEBLER, PETER J.; MEHROTRA, MEGHA L.; SHAW, BRIAN I.; LEADABRAND, KAITLYN S.; MILUSH, JEFFREY M.; YORK, VANESSA A.; DEFECHEREUX, PATRICIA; GRANT, ROBERT M.; KALLAS, ESPER G.; NIXON, DOUGLAS F.. Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8(+) T-Cell Activation. Journal of Infectious Diseases, v. 213, n. 4, p. 569-573, FEB 15 2016. (04/15856-9, 10/05845-0)