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Institute for Investigation in Immunology

Grant number: 08/57881-0
Support type:Research Projects - Thematic Grants
Duration: March 01, 2009 - February 28, 2015
Field of knowledge:Biological Sciences - Immunology
Cooperation agreement: CNPq - INCTs
Principal Investigator:Jorge Elias Kalil Filho
Grantee:Jorge Elias Kalil Filho
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Immunology was the first branch of medicine to develop and use biodrugs. Today, approximately 40 monoclonal antibodies and recombinant proteins are in use in clinical practice and another 50 are being evaluated in clinical trials for the treatment of different immunologic and hemathologic diseases, cancer, allergies and graft rejection. In spite of the considerable advances in our cellular and molecular understanding of the pathologic processes that affect humans, our understanding of the mechanisms behind many diseases are still lagging, and therefore so is treatment. The progress in the immunotherapy and diagnosis of many diseases is hampered by our inability to define the complex molecular pathways behind these diseases, suggesting that and integrated approach that includes clinical, molecular, epidemiologic tools as well as bioinformatics will be required to find solutions for these questions. The recent failure in the development of promising novel HIV vaccines indicate that broader approaches are required to innovate in vaccine design. The same paradigm applies to cancer treatment, immunotherapy for graft rejection, infectious diseases, autoimmune diseases and allergies. The ineffectiveness of contemporary science to understand complex biological systems with multi pie parallel interactions, has Iimited the speed with which the knowledge acquired by basic scientists is translated into gains to human health. It is well established today that several diseases of previously unknown etiology are due to dysfunctions of the immune system, either by excessive or inadequate inflammatory responses. The Institute for Investigation in Immunology (III), one of the original Millennium Institutes funded by the Ministry of Science and Technology in 2001, is precisely focused on this issue. Our areas of interest (autoimmune diseases, immunodeficiencies and HIV/AIDS, leishmaniasis, transplants, cancer and allergies) pertain to health problems that affect millions of people in Brazil and all throughout the world. Besides its socio-economic relevance, these diseases are relevant biological models since their study allow the advancement of knowledge of pathophysiologic mechanisms and, therefore, leading to the design of therapeutic strategies based on disease pathogenesis. During its second phase (2005-2008), the III investigators successfully mentored 76 M. Sci. students, 66 Ph.D. students; trained 35 post-doctoral fellows; conducted 2 clinical trials and requested 3 international patents. The scientific output of the 31 members of the Institute during the 2005-2007 period was equivalent to 23% of the indexed national publications in immunology (435 papers from the III out of 1917 Immunology papers from all Brazilian scientists, data from? currículo Lattes? and Scimago, www.scimagojr.com). These data show that how solid our basic research background is, the true source for new discoveries with potential health applications. The III aims to develop translational research to test, in humans, innovative immunotherapeutic approaches developed through experimentation in disease models... (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Novel Brazilian HIV vaccine strategy will be tested in monkeys 
Researchers patent compound to fight rheumatic fever bacteria  
Articles published in Pesquisa FAPESP Magazine about the research grant:
Allergies make us moody 

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS, CARLO DE OLIVEIRA; DEMARCHI, LEA; FERREIRA, FREDERICO MORAES; ALBERTO POMERANTZEFF, PABLO MARIA; BRANDAO, CARLOS; SAMPAIO, RONEY ORISMAR; SPINA, GUILHERME SOBREIRA; KALIL, JORGE; CUNHA-NETO, EDECIO; GUILHERME, LUIZA. Rheumatic Heart Disease and Myxomatous Degeneration: Differences and Similarities of Valve Damage Resulting from Autoimmune Reactions and Matrix Disorganization. PLoS One, v. 12, n. 1 JAN 25 2017. Web of Science Citations: 1.
SANTANA, VINICIUS CANATO; ALMEIDA, RAFAEL RIBEIRO; RIBEIRO, SUSAN PEREIRA; DE SOUZA FERREIRA, LIUS CARLOS; KALIL, JORGE; ROSA, DANIELA SANTORO; CUNHA-NETO, EDECIO. Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4(+) T-cell responses. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. 1010-1016, DEC 2015. Web of Science Citations: 6.
ALMEIDA, RAFAEL RIBEIRO; RAPOSO, RUI ANDRE SARAIVA; COIRADA, FERNANDA CAROLINE; DA SILVA, JAMILE RAMOS; DE SOUZA FERREIRA, LUIS CARLOS; KALIL, JORGE; NIXON, DOUGLAS F.; CUNHA-NETO, EDECIO. Modulating APOBEC expression enhances DNA vaccine immunogenicity. Immunology and Cell Biology, v. 93, n. 10, p. 868-876, NOV 2015. Web of Science Citations: 3.
VINICIUS CANATO SANTANA; RAFAEL RIBEIRO ALMEIDA; SUSAN PEREIRA RIBEIRO; LUÍS CARLOS DE SOUZA FERREIRA; JORGE KALIL; DANIELA SANTORO ROSA; EDECIO CUNHA NETO. Co-administration of plasmid-encoded granulocyte-macrophage colony-stimulating factor increases human immunodeficiency virus-1 DNA vaccine-induced polyfunctional CD4+ T-cell responses. Memórias do Instituto Oswaldo Cruz, v. 110, n. 8, p. -, Dez. 2015.
PINTO FERREIRA, LUDMILA RODRIGUES; FRADE, AMANDA FARAGE; BARROS SANTOS, RONALDO HONORATO; TEIXEIRA, PRISCILA CAMILLO; BARON, MONIQUE ANDRADE; NAVARRO, ISABELA CUNHA; BENVENUTI, LUIZ ALBERTO; FIORELLI, ALFREDO INACIO; BOCCHI, EDIMAR ALCIDES; STOLF, NOEDIR ANTONIO; CHEVILLARD, CHRISTOPHE; KALIL, JORGE; CUNHA-NETO, EDECIO. MicroRNAs miR-1, miR-133a, miR-133b, miR-208a and miR-208b are dysregulated in Chronic Chagas disease Cardiomyopathy. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 175, n. 3, p. 409-417, AUG 20 2014. Web of Science Citations: 33.
ALMEIDA, RAFAEL RIBEIRO; ROSA, DANIELA SANTORO; RIBEIRO, SUSAN PEREIRA; SANTANA, VINICIUS CANATO; KALLAS, ESPER GEORGES; SIDNEY, JOHN; SETTE, ALESSANDRO; KALIL, JORGE; CUNHA-NETO, EDECIO. Broad and Cross-Clade CD4(+) T-Cell Responses Elicited by a DNA Vaccine Encoding Highly Conserved and Promiscuous HIV-1 M-Group Consensus Peptides. PLoS One, v. 7, n. 9 SEP 18 2012. Web of Science Citations: 19.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.